WG4 - Novel Technologies and Future Developments
Leader Natal van Riel
For the EU to be world leading in this field it is necessary to ensure continuous development of technologies which accelerate testing, reduce costs and improve quality of data and animal welfare. Imaging technologies and multiscale predictive models of organisms are emerging as areas of strength in Europe, which can fulfil these needs.
- Constitute collaborative groups with expertise in imaging (in vivo, longitudinal) and mathematical modelling in mouse models.
- Work with the other working groups to identify gaps and limitations in current approaches.
- Explore and develop opportunities of novel technologies to contribute to preclinical research on ageing, frailty and multimorbidity.
- Identify new developments to improve testing and reduce the number of animals.
Progress to date:
- A review on ‘Longitudinal imaging of the ageing mouse’ has been published. See MouseAGE special issue of Mechanisms of Ageing and Development.
- A workshop was organized to make an inventory of areas in the research on pathologies, interventions and/or ageing in mice where computational models are being developed. Details can be found HERE.
- A training school is organized to introduce researchers with an experimental background in the field of mathematical and computational modelling. Details can be found HERE.
- A paper which provides an overview of the applications of the most commonly used in vivo imaging modalities used in mouse studies. See https://www.sciencedirect.com/science/article/pii/