Professor Luigi Fontana

Working group 3
Management Committee
University of Brescia
  • Italy

Luigi Fontana is an internationally known physician scientist and one of the world’s leaders in the field of nutrition and healthy aging in humans. His pioneering studies on the effects of dietary restriction in humans have opened a new area of nutrition-related research that holds tremendous promise for the understanding of the biology of human aging and the promotion of healthy longevity.  He is currently a Full Professor of Medicine and Nutritional Sciences at Brescia University (Italy) and at Washington University in St.Louis (USA).  Fontana graduated with highest honors from the Verona University Medical School (1994), where he completed his internship and residency in Internal Medicine (1999). He also received a Ph.D. in Metabolism and Clinical Pharmacology from the University of Padua Medical School (2004).

Fontana's research interests lie in preventive medicine and in the mechanisms mediating healthy longevity in humans. His research focus primarily on the role of diet, physical exercise and CR mimetics in retarding the aging process and in preventing age-associated chronic disease in humans. In particular, he is applying whole-body physiological and tissue-specific molecular approaches to investigate the effects of several clinical interventions, including calorie restriction, intermittent fasting, protein or amino acid restriction, phytochemical-rich plant-based diets, physical exercise and CR mimetics, on outcomes such as cardiovascular function, glucose metabolism, inflammation, neuroendocrine and immune function, gut microbiome and cancer biology. He is also interested in the endocrine role of abdominal fat storage as a mediator of insulin resistance and accelerated aging.