Professor Isabel Varela-Nieto

Professor Isabel Varela-Nieto
Working group 2 & 3
Management Committee
Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER)
  • Spain

Prof. Isabel Varela-Nieto, PhD in Biochemistry from the “Universidad Complutense de Madrid”, is a researcher at CIBERER and Research Professor at the Institute for Biomedical Research "Alberto Sols", where she heads the Group of Neurobiology of Hearing ( She is the scientific supervisor of the Network for the phenotyping of laboratory animal models of human diseases (SEFALer; of the CIBERER.

Her research is focused in the study of the genetic and molecular bases of age-related hearing loss (ARHL), with a focus on: i) insulin like growth factor I and its intracellular targets; ii) the impact of genetic and environmental factors, as noise exposure; and iii) the oxidative-inflammatory status. These objectives are approached by the development and evaluation of cellular and animal models, and by using non-invasive neurophysiological techniques for studying the auditory function.

Our aims are to increase basic knowledge in the field of ARHL, to contribute to the development of new therapies for auditory repair and regeneration, and finally to make contributions which may improve human health in the medium or long term.

Author of more than 125 articles in international scientific journals, reviews and book chapters (, she coordinates the FP7-PEOPLE-TARGEAR Marie S. Curie Action ( for the study of ARHL.

Related Links

Key Words

Ageing, hearing, deafness, noise-induced hearing loss, ototoxicity, sensory systems, auditory physiopathology, nervous system, neurobiology, animal models of human deafness, preclinical studies, molecular medicine, autophagy, apoptosis, senescence, cell signalling, insulin-like growth factors, kinases  RAF, AKT, p38.