MouseAGE member, Dr. Ralph Müller received this year an Advanced Grant of the European Research Council (ERC). His awarded project, "MechAGE – In vivo single-cell mechanomics of bone adaptation and regeneration in the aging mouse", is directly related to the MouseAGE activities and was very much inspired by all the discussions had so far in the aim of the consortium about investigating and modeling the aging mouse.
Ralph Müller, Professor of Biomechanics, is interested in how mechanical vibrations influence bone development. His main focus is the understanding of how bones adapt and regenerate over the course of a lifetime. In his ERC project, Müller aims to investigate which cell types are involved in these processes and how these cells react to age-related change. Specifically, he wants to use genome sequencing of single cells to understand how molecular ageing processes under mechanical loads affect bone remodelling. In the future, this understanding may facilitate targeted exercise programmes within the context of personalised medicine to foremost prevent osteoporosis-related bone fractures or at least heal them more quickly.
The project will be funded with a total of 2.5 Million € over the next five years. Such award reinforces the relevance and importance of MouseAGE field of research.