News

MouseAGE meeting programme: Geroprotectors: achievements and challenges

The MouseAGE meeting Geroprotectors: achievements and challenges was successfully held at the Università Cattolica del Sacro Cuore, Rome, Italy on 24th – 25th September 2018.

The key themes discussed at the meeting were:

  • What’s exciting in healthspan and geroprotectors
  • Multimorbidity and Digital Health
  • Frailty and resilience

The programme can be found below.

Useful Downloads: 

MouseAGE Models of Ageing and Age-related Diseases database live

The MouseAGE Models of Ageing and Age-related Diseases database is now live on the MouseAGE website at: https://www.mouseage.eu/domains

The database has a particular emphasis on data which may never be published but are helpful in designing experiments, i.e. negative results or timing of appearance of specific phenotypes.

Further contributions to the database are sought and will be accepted until 30 November 2018. If you have data you wish to add to the database, please download and complete the form in the 'useful documents' section below. Return the completed template to mouseage@sheffield.ac.uk. For a MS Word version of the template, please contact mouseage@sheffield.ac.uk

If your data is confidential but you still wish to contribute, please just provide your name, email, institution, the relevant ageing or age-related disease, model and whether its clinically relevant to mouseage@sheffield.ac.uk. Only this high level information will be published on the database and those interested in further information will be encouraged to contact you directly via email.

 

 

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2018 MouseAGE Training School

Eighteen participants took part in the MouseAGE Training School Behavioural Phenotyping in mice - focus on longitudinal studies in ageing on 10-12 July 2018 at the Instituto de Investigaciones Biomédicas “Alberto Sols”, Madrid, Spain. 

Organised by MouseAGE Core Group member, Dr José Luis Trejo, the training school was directed at both beginners and experimenters with some ability in behavioural phenotyping who wanted to extend their knowledge in the specific tasks and their application to ageing mice. Following the successful completion of the training school, participants are now able to:

  • Design basic experiments based on Morris water maze protocols, object recognition tests, auditory brain stem response, or acoustic startle response, with a specific focus to ageing studies
  • Perform the technical execution of the different tests and protocols
  • Manage and analyse the data

 

Useful Downloads: 

MouseAGE Meeting ROME 2018 - Call for bursary applications and abstracts

COST Action BM1402 is pleased to announce that calls for bursary applications and abstracts are now open for the MouseAGE meeting:
Geroprotectors: achievements and challenges

Rome, Italy

24th – 25th September 2018

The meeting will take place at the Università Cattolica del Sacro Cuore and will start at 9am on Monday 24th September and conclude at 4pm on Tuesday 25th September.

The key themes to be discussed are:
·        What’s new in healthspan and geroprotectors
·        Models of frailty and resilience
·        Multimorbidity and digital health

Speakers at the meeting will include Dan Ehninger (German Center for Neurodegenerative Diseases, Germany), Costas Bekas (IBM Research Zurich, Switzerland), Alessandra Marengoni (University of Brescia, Italy) and Alessandro Blasimme (ETH Zurich,Switzerland).

There are a number of bursaries available for researchers to attend the meeting - these will cover accommodation, travel and meals in line with COST reimbursement rules. COST rules on reimbursement are detailed in the COST vademecum which can be found here: http://www.cost.eu/participate. Reimbursement will occur after the meeting.

Please use the form HERE to register your interest in attending the meeting, apply for a bursary and submit your abstract. Submitted abstracts should also be emailed to mouseage@sheffield.ac.uk.

Deadline for submitting the form is Wednesday 4th July 2018.

Applicants will be notified on the outcome of their bursary and abstract applications within two weeks of the close date (4 July).

Please contact mouseage@sheffield.ac.uk if you have any questions.

ITC Conference Grants Open

ITC Conference Grants are exclusively reserved for PhD students and early career investigators (ECIs) with a primary affiliation in an institution located in an ITC. ITCs are Bosnia-Herzegovina, Bulgaria, Cyprus, Czech Republic, Estonia, Croatia, Hungary, Lithuania, Latvia, Luxembourg, Malta, Montenegro, Poland, Portugal, Romania, Slovenia, Slovakia, the former Yugoslav Republic of Macedonia, Republic of Serbia and Turkey.

The applicant must make an oral or poster presentation at the conference and must be listed in the official event/conference programme. The main subject of the presentation must be in line with the objectives of the MouseAge action BM1402 and COST must be acknowledged.

The proposed conference to be attended must take place before 1 November 2018.  Attendance at European conferences is preferred. However, conferences held elsewhere can also be considered. Conferences, meetings and other activities organized by COST/MouseAGE are not eligible.

A Conference Grant is a contribution towards the conference fee, overall travel, accommodation and meal expenses of the selected Grantee. The calculation of the financial contribution for each Conference Grant must respect the following criteria:

  • Up to a maximum of €2500 in total can be claimed by each successful applicant;
  • Up to a maximum of €160 per day can be claimed for accommodation and meal expenses;
  • Up to a maximum of €500 can be claimed for the conference fees to be incurred by the selected Grantee.

 Applications containing the following information should be sent to Mouseage@sheffield.ac.uk:

- CV

- Motivation letter containing: (1) detailed information about the conference, (2) motivation how attending is going to benefit the applicant, (3) motivation in what way the conference themes align with the aims of the MouseAge Action, and (4) a clear breakdown of the budget requested.

- Abstract of oral / poster presentation

- Evidence of acceptance to conference and the conference fee amount

MouseAGE ITC Conference Grant applications can be submitted until 15 June 2018. The applications will be reviewed by the MouseAge Action core group based on the above-mentioned criteria and applicants will be notified of the outcome as soon as possible after 15 June.

After the conference the successful applicants must submit a scientific report (template available and mandatory), travel documentation, and fee invoice (if applicable) within 15 days.  The grant is only paid after submission of the requested information.

 

Applications Open for MouseAGE Training School

COST Action BM1402 - Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers to apply for the following training school:

Behavioural Phenotyping in mice: Focus on longitudinal studies in ageing
10th-12th July 2018
Instituto de Investigaciones Biomédicas “Alberto Sols”, MADRID, SPAIN


A provisional programme for the training school can be downloaded below.

There are 18 places available for this training school. 

A bursary of 780 EURO will be available to participants as a contribution to the cost of travel, accommodation and meal expenses incurred. 

Those wishing to apply should complete the form at: 

https://goo.gl/forms/MkTrHbmHYz9ov7CG3 

Applicants should include details of their motivation for applying for this training school, why they wish to attend and how it will benefit their research, career and CV. 

They should also send their CV to mouseage@sheffield.ac.uk

Applications close Monday 7 May 2018. Successful applicants will be notified by Monday 21 May 2018. 

If selected to participate in the training school, you will receive an invitation via the e-COST portal. After accepting the invitation, participants will be eligible for reimbursement according to COST rules. Further details will be sent to successful applicants. 

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Coming Events

The final MouseAGE Training School entitled 'Behavioural Phenotyping in mice: Focus on longitudinal studies in ageing' will be held at Autonoma University of Madrid on 10 - 12 July 2018. Grant application details will be provided shortly.

The final MouseAGE meeting will be held in Rome on 24 - 25 September 2018. Please keep these dates free in your diary if you plan to attend. Venue, programme details etc. will be provided as soon as they are available.

Open call for contributions

Open call for contributions for the special track “Prevention and mitigation of frailty through physical exercise interventions”

(http://www.tishw.ws/2018/special-tracks/)

2nd International Conference on Technology and Innovation in Sports, Health and Wellbeing, June 20-22, 2018, Aristotle University of Thessaloniki, Greece.

INFRAFRONTIER2020 Project - Trans-national Access call - November 2017

Call for information and applications (November 2017): INFRAFRONTIER2020 Project - Trans-national Access

INFRAFRONTIER Research Infrastructure - Precision mammalian model development

Context and aim of the call 
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA) (www.infrafrontier.eu).

Main objective of this INFRAFRONTIER open call is to facilitate access for the wider biomedical research community to the unique infrastructure and scientific expertise of the participating INFRAFRONTIER partners, to deliver novel mouse lines that will advance knowledge of human disease and will be of widespread use in biomedical science. Recent advances in genome editing technology will be used to develop new mouse models of human disease. INFRAFRONTIER will provide open access to all newly developed disease models through the European Mouse Mutant Archive (EMMA). Access to this free-of-charge-service will be granted on the basis of the applicant's research plans and the potential impact of the proposed novel mouse line on the wider biomedical research community.

During the course of the INFRAFRONTIER2020 project a total of 3 Trans-national Access calls for the development of mammalian model development supporting a total of 28 projects will be published. Further calls supporting 10 mouse model and 6 rat model development projects will be released in 2018.

More information and call application form: https://www.infrafrontier.eu/resources-and-services/infrafrontier-open-calls/precision-mammalian-model-development 
Proposal submission to proposals@infrafrontier.eu by 20 December 2017.
Proposal evaluation from 21 December 2017 to 15 February 2018.
The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU.1.4.1.1. Developing new world class research infrastructures)


Trans-national Access (TA) activity of the INFRAFRONTIER2020 project
Free of charge precision mammalian model development service / Access modalities

  • The EC Horizon 2020 funded INFRAFRONTIER2020 project (2017 – 2020) supports eligible customers with a free-of-charge mouse model development service implemented as a Trans-national Access activity supporting a total of 12 projects in this first call.
  • The access unit offered covers the production of a single F1 genome-edited mouse line (at least one individual of a F1 genome edited mouse line will be provided).
  • The model development service involves project design including prediction of off-target sites, preparation of sgRNA's and Cas9 mRNA/protein, and injection into zygotes to generate F0 founder mutant animals (C57BL/6N or C57BL/6J genetic background preferred). Selected F0 animals will be bred to germ line to produce F1 genome edited animals. Possible allele types that can be generated are indels, exon deletions (< 10kb) and point mutation insertions. Newly developed mouse models will be made available to selected applicants within an average of 12 months following provision of all required information to start the mouse production.
  • The generated mouse models will be made available to the scientific community. An optional grace period of up to 1 year for mouse resources may apply, with immediate release of mouse resources after expiry of the grace period. Mouse mutant lines will be deposited into the INFRAFRONTIER/EMMA repository for subsequent use by the scientific community. Newly developed mouse models will be owned by the production centres and will be distributed by the INFRAFRONTIER/EMMA repository using their institutional MTAs.
  • Costs: The access to the INFRAFRONTIER2020 model development service is free of charge. However, the shipment cost of the newly developed mouse models must be borne by the applicants.
  • Eligibility: The INFRAFRONTIER2020 Trans-national Access call is open and proposals can be submitted from applicants around the world. Ten projects must be allocated to applicants from EU Member States and Associated Countries, and two projects can be allocated to applicants from third countries.
  • Application: Service requests for the INFRAFRONTIER2020 model development service can be made via an application form. Applications for the Trans-national Access activity must include a short description of the research plans for utilising the newly developed mouse model that is being generated by the INFRAFRONTIER2020 TA service.
  • Selection procedure: Proposals from eligible customers for free of charge access to the INFRAFRONTIER2020 mouse model development service will be subject to a review procedure. The review will be based on short descriptions of the projects involving the mouse mutants that will be produced by the TA service. A mixed panel of members of INFRAFRONTIER and of an external Evaluation Committee will assess service requests supported by the TA activity. In addition to scientific merit of applicants, soundness of the proposal and research plans, and the beneficial impact of the proposed novel mouse line on the wider biomedical research community will be assessed. Applicants will be informed on the outcome of the evaluation within 6 weeks after the end of the call for which the TA application was submitted. All applications will be handled with strict confidentiality.
  • Acknowledgements: Please do acknowledge any support under this scheme in all resulting publications with "Part of this work has been funded by the European Union Research and Innovation programme Horizon 2020 (Grant Agreement Number 730879). The participating infrastructure which provided the service should be specifically mentioned in any publication resulting from the service.

A call is now open for Inclusiveness Target Countries (ITC) Conference Grants

ITC Conference Grants are exclusively reserved for PhD students and early career investigators (ECIs) with a primary affiliation in an institution located in an ITC. ITCs are Bosnia-Herzegovina, Bulgaria, Cyprus, Czech Republic, Estonia, Croatia, Hungary, Lithuania, Latvia, Luxembourg, Malta, Montenegro, Poland, Portugal, Romania, Slovenia, Slovakia, the former Yugoslav Republic of Macedonia, Republic of Serbia and Turkey.

The applicant must make an oral or poster presentation at the conference and must be listed in the official event/conference programme. The main subject of the presentation must be in line with the objectives of the MouseAge action BM1402 and COST must be acknowledged.

The proposed conference to be attended must take place before 30 March 2018.  Attendance at European conferences is preferred. However, conferences held elsewhere can also be considered. Conferences, meetings and other activities organized by COST/MouseAGE are not eligible.

A Conference Grant is a contribution towards the conference fee, overall travel, accommodation and meal expenses of the selected Grantee. The calculation of the financial contribution for each Conference Grant must respect the following criteria:

  • Up to a maximum of €2500 in total can be claimed by each successful applicant;
  • Up to a maximum of €160 per day can be claimed for accommodation and meal expenses;
  • Up to a maximum of €500 can be claimed for the conference fees to be incurred by the selected Grantee.

 Applications containing the following information should be sent to Mouseage@sheffield.ac.uk:

- CV

- Motivation letter containing: (1) detailed information about the conference, (2) motivation how attending is going to benefit the applicant, (3) motivation in what way the conference themes align with the aims of the MouseAge Action, and (4) a clear breakdown of the budget requested.

The applications will be reviewed by the MouseAge Action core group based on the above-mentioned criteria and will be awarded on a first come first served basis.

After the conference the successful applicants must submit a scientific report (template available and mandatory), travel documentation, and fee invoice (if applicable) within 15 days.  The grant is only paid after submission of the requested information.

For more information see inclusiveness_target_countries_conference_userguide.pdf

Useful Downloads: 

INFRAFRONTIER2020 axenic service call

INFRAFRONTIER Research Infrastructure
INFRAFRONTIER2020 Project - Trans-national Access call - July 2017
Derivation of germ-free mice (axenic service) call
Call information and application form

Context and aim of the call
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA) (www.infrafrontier.eu). 

INFRAFRONTIER2020 project and microbiome research 
One of the INFRAFRONTIER2020 project aims is to develop pilot platforms and services supporting microbiome research. A service to derive germ-free (axenic) mice is now provided by three infrastructures with a long standing expertise and track record in the derivation of axenic and gnotobiotic mice, namely the Gnoto / Axenic Facility of the Instituto Gulbenkian de Ciência, the Karolinska Institutet Core Facility for Germ-free Research, and the CNRS Service Isotechnie of the PHENOMIN-TAAM infrastructure. The Karolinska Institutet has maintained a unique platform for the handling and derivation of gnotobiotic models kept under germ-free (GF) conditions since the 1960s. All infrastructures are partners and founding members of the ECGnoto network. 

The participating INFRAFRONTIER infrastructures are among very few dedicated facilities in Europe who have the required equipment and expertise to generate germ-free and gnotobiotic mice. All infrastructures routinely offer their services to external users. The participating axenic- and gnotobiology platforms support research into host-microbiota interactions to study the role of the microbiome in both health and disease. This has been the subject of extensive research and established the involvement of the microbiome in metabolism, nutrition, physiology, and immune function and showed that mammalian microbiota play crucial roles in the pathogenesis of many diseases. 

Access to the axenic service will be granted on the basis of scientific excellence and supports pilot projects for the derivation of-germ-free mice. Further breeding and characterisation of axenic mice or the development of gnotobiotic models can be offered on a fee-for-service or on a collaborative basis. 

During the course of the INFRAFRONTIER2020 project a total of 2 Trans-national Access calls for the derivation of germ-free mice supporting a total of 10 projects will be published. The second call will be released in spring 2018. 

More information and call application form: https://www.infrafrontier.eu/resources-and-services/axenic-service/infrafrontier-axenic-germ-free-service

Proposal submission to proposals@infrafrontier.eu by August 31st 2017. Proposal evaluation from September 1st to October 15th 2017. 
The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU.1.4.1.1. Developing new world class research infrastructures) 


Trans-national Access (TA) activity of the INFRAFRONTIER2020 project Free of charge mouse late-onset phenotyping service / Access modalities 

· The EC Horizon 2020 funded INFRAFRONTIER2020 project (2017 – 2020) supports eligible customers with a free of charge mouse axenic service implemented as a Trans-national Access activity providing a total of 5 access units in this first call. 
· The access unit offered covers the derivation of germ-free (axenic) mice from a breeding nucleus or from frozen materials provided by the applicants. Mice will be kept under germ-free conditions for 6-8 weeks. 
· Mutant mouse lines will be provided by the selected applicants as live animals (minimum of 10 females and 5 males) or quality controlled frozen embryos or sperm(minimum of 40 embryos or 2 straws of sperm). The participating infrastructures will transfer and breed mice under SPF conditions, and then introduce and foster 2 litters or 8 animals into one germ-free isolator until 2 months of age. Tissues or body fluids can be provided or arrangements are made for live germ-free shipments. 
· Costs: The access to the INFRAFRONTIER2020 axenic service is free of charge. However, the shipment cost of the starting material (breeding pairs or frozen material) to the infrastructures as well as a possible live germ-free animal shipment must be covered by the applicants. Extended breeding and other complementary services can be offered on a fee-for service or on a collaborative basis. 
· Eligibility: The INFRAFRONTIER2020 Trans-national Access call is open and proposals can be submitted from applicants around the world. Four projects must be allocated to applicants from EU Member States and Associated Countries, and one project can be allocated to applicants from third countries. 
· Application: Service requests for the INFRAFRONTIER2020 mouse axenic service can be made via an application form (https://www.infrafrontier.eu/resources-and-services/axenic-service/infrafrontier-axenic-germ-free-service). Applications for the Trans-national Access activity must include a short description of the project involving the germ-free mouse mutant being generated by the INFRAFRONTIER2020 TA service. 
· Selection procedure: Proposals from eligible customers for free of charge access to the INFRAFRONTIER2020 mouse axenic service will be subject to a review procedure. The review will be based on short descriptions of the projects involving the mouse mutants that will be made germ-free by the TA service. A mixed panel of members of INFRAFRONTIER and of an external Evaluation Committee will assess service requests supported by the TA activity. In addition to scientific merit of applicants, soundness of the proposal, relevance for microbiome research and feasibility will be assessed. Applicants will be informed on the outcome of the evaluation within 6 weeks after the end of the call for which the TA application was submitted. All applications will be handled with strict confidentiality. 
· Acknowledgements: Please do acknowledge any support under this scheme in all resulting publications with "Part of this work has been funded by the European Union Research and Innovation programme Horizon 2020 (Grant Agreement Number 730879). The participating infrastructure which provided the service should be specifically mentioned in any publication resulting from the service. 
· Disclaimer: Certain mouse lines may not breed under axenic conditions, and derivation attempts will then be discontinued. Two attempts will be made to derive germ-free mice for each access unit. 

 

7th Call of STSM is now open

COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers from Participating COST Countries to submit applications for the 7th call for STSMs.


Purpose of a STSM
STSM are aimed at strengthening existing networks and fostering collaborations by allowing researchers participating in a given COST Action to visit an institution or laboratory in another Participating COST Country / an approved Near Neighbour Country institution or an approved International Partner Country institution. A STSM should specifically contribute to the overall scientific objectives of the COST Action, whilst at the same time enable researchers to learn new techniques or gain access to specific expertise, instruments and/or methods not available in their own institutions. 

We welcome applications that are aligned with MouseAGE’s current scientific priorities.  

Full details of the current MouseAGE priorities can be found on the website (www.mouseage.eu) and the scientific objectives of COST Action BM1402 are available in the Memorandum of Understanding which can be downloaded here:  http://www.cost.eu/COST_Actions/bmbs/Actions/BM1402.

Complete information regarding STSMs can be found here.

INFRAFRONTIER Research Infrastructure

INFRAFRONTIER2020 Project - Trans-national Access call - June 2017
Late-onset systemic phenotyping (ageing pipeline)


Call information and application form


Context and aim of the call 
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA) (www.infrafrontier.eu).


INFRAFRONTIER2020 project and ageing 
The INFRAFRONTIER2020 project aims to develop pilot platforms and services supporting ageing research. These activities are tightly integrated with the current efforts of the International Mouse Phenotyping Consortium (IMPC, www.mousephenotype.org) to set up a standardised late-onset (ageing) pipeline. In the IMPC phase 2 a significant fraction of mutant lines will be aged and re-phenotyped to identify genes involved with late-onset disease. The INFRAFRONTIER2020 Trans-national Access call complements the highly standardised IMPC late-onset phenotyping, as existing mouse lines with different mutations and genetic backgrounds can be tested with the IMPC late-onset phenotyping pipeline.

The INFRAFRONTIER open call facilitates access for the wider biomedical research community to the unique infrastructure and scientific expertise of the MRC Harwell mouse clinic. A total of four mouse mutant lines can be tested through a broad based late-onset phenotyping pipeline in all the major adult organ systems and most areas of major human disease and will be re-phenotyped at a later stage (weeks 52-59). Access to the service will be granted on the basis of scientific excellence and supports the development and in depth characterisation of mouse models for research on ageing and age-related diseases. INFRAFRONTIER will provide open access to all tested mouse lines and their phenotyping data.

More information and call application form: https://www.infrafrontier.eu/resources-and-services/infrafrontier-open-calls/late-onset-systemic-phenotyping-ageing-pipeline 

Proposal submission to proposals@infrafrontier.eu by June 30th 2017.
Proposal evaluation from July 1st to August 15th 2017.
The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU.1.4.1.1. Developing new world class research infrastructures)


Trans-national Access (TA) activity of the INFRAFRONTIER2020 project
Free of charge mouse late-onset phenotyping service / Access modalities

  • The EC Horizon 2020 funded INFRAFRONTIER2020 project (2017 – 2020) supports eligible customers with a free of charge mouse late-onset phenotyping service implemented as a Trans-national Access activity providing a total of 4 access units.
  • The access unit offered covers the production of a cohort and a comprehensive first line phenotyping. The phenotyping will be performed at two different ages so that late onset of disease can be measured and / or the progression of disease with age.
  • Mutant mouse lines will be provided by the selected applicants either as breeding pairs or frozen embryos or sperm. MRC Harwell will breed the cohorts required for the pipelines, use the IMPC late-onset phenotyping pipeline and perform any relevant additional tests. Health status requirements to accept animals will be provided.
  • The phenotyping data will be made publicly available through a phenotyping database or as a phenotyping report. Successful applicants must submit phenotyped mouse mutant lines to the EMMA repository. An optional grace period of up to one year can be granted before data and mutant mouse lines must be released.
  • Costs: The access to the INFRAFRONTIER2020 phenotyping service is free of charge. However, the shipment cost of the starting material (breeding pairs or frozen embryos) to the MRC Harwell mouse clinic must be covered by the customers.
  • Eligibility: The INFRAFRONTIER2020 Trans-national Access call is open and proposals can be submitted from applicants around the world. Three projects must be allocated to applicants from EU Member States and Associated Countries, and one project can be allocated to applicants from third countries.
  • Application: Service requests for the INFRAFRONTIER2020 mouse phenotyping service can be made via a dedicated application form. Applications for the Trans-national Access activity must include a short description of the project involving the mouse mutant being phenotyped by the INFRAFRONTIER2020 TA service.
  • Selection procedure: Proposals from eligible customers for free of charge access to the INFRAFRONTIER2020 mouse phenotyping service will be subject to a review procedure. The review will be based on short descriptions of the projects involving the mouse mutants that will be phenotyped by the TA service. A mixed panel of members of INFRAFRONTIER and of an external Evaluation Committee will assess service requests supported by the TA activity. In addition to scientific merit of applicants, soundness of the proposal, relevance for ageing research and feasibility will be assessed. Applicants will be informed on the outcome of the evaluation within 6 weeks after the end of the call for which the TA application was submitted.

Training School - Drug Discovery and Development

COST Action BM1402 - Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers to apply for the following training school:


Drug Discovery and Development
4th-6th October 2017
Novartis Campus, Basel, Switzerland

 

The training school aims to give insights into drug discovery and development. The core of the course is an interactive and group discussion simulation of a drug discovery project from discovering to launching a new medicine. Each participant will be assigned a role in the project team and need to come prepared to the course. Participants will encounter and make decisions about various scientific challenges and possible research path. The team will choose a therapeutic indication and drug target, search for potential chemical leads, optimize and progress these leads through preclinical research, demonstrating that selected drug candidate is safe and effective in patients, advance the drug through clinical trials, and ultimately submit the drug for registration with health authorities.

 

A provisional programme for the training school is provided in Useful downloads.

There will be 18 places available for this training school. Please note that attendance at this training school requires that some pre-course preparation will need to be completed. A bursary of 780 EURO will be available to participants as a contribution to the cost of travel, accommodation and meal expenses incurred. 

Those wishing to apply should complete the following form: https://goo.gl/forms/kYWQDAHZnmbfEG8B2. Applicants should include details of their motivation for applying for this training school, why they wish to attend and how it will benefit their research, career and CV. They should also send their CV to mouseage@sheffield.ac.uk

The closing date for applications is Friday 23rd June 2017, successful applicants will be notified by Friday 14th July 2017

 

If selected to participate in the training school, you will receive an invitation via the e-COST portal. After accepting the invitation, participants will be eligible for reimbursement according to COST rules. Further details will be sent to successful applicants. 

 

Useful Downloads: 

3rd Course Mouse and Rat Bone Phenotyping

== LAST CHANCE for applying to the "3rd Course on Mouse and Rat Bone Phenotyping" ==

=== 31st MAY FINAL DEADLINE===

 

Objective of the Course: The aim of this course is capacitating participants to localize and to interpret the most common skeletal alterations found in mice and rats. This will occur in the context of dedicated learning sessions devoted to the study of bone anatomy, histology, immunohistochemistry, ultrastructure and imaging. Each lecture will be followed by a practical session in which participants will work with real bone specimens,radiographs,histological preparations, and images from TEM and micro-CT. In addition, the course will include seminars where specific skeletal abnormalities found in mutant mice will be discussed.

Duration: 4 days. 10-13 July 2017

Number of participants: 15 max

The course will be held at the Center for Animal Biotechnology and Gene Therapy (CBATEG) and the School of Veterinary Medicine at the Universitat Autònoma de Barcelona (www.uab.cat)

Tuition fee: € 950

DEADLINE FOR APPLICATIONS: 31st May 2017
Applications should be sent to: victor.nacher@uab.cat

Detailed information can be found in Useful Downloads.

Useful Downloads: 

Postdoctoral Research Position at CEDOC, Portugal

Postdoctoral Research Position - Lysosome dysfunction in Age-related macular degeneration

A Postdoctoral position is available in the laboratory of Miguel Seabra, at the CEDOC - Chronic Diseases Research Center, Nova Medical School, Lisbon, Portugal.

In this work we aim to test new therapeutic approaches for Age-related macular degeneration (AMD). We hypothesise that AMD has it origin in the retinal pigment epithelium (RPE) due to chronic dysfunction of the lysosome. Cellular models of AMD will be generated using cell cultures of retinal pigment epithelium (RPE) and will be tested compounds that could improve lysosomal function. The results to be obtained in cellular models will guide future tests in animal models.

This grant is for 6 months, but could be extended if funding is renewed.

Please send your application including your CV, contact details, PhD certificate, a letter of motivation, and the names and contact information of two references to applications@nms.unl.pt with the subject “DAI/2017/14 application” from 10th April to 24th April 2017. More details about this application can be found here. 

ERC Advanced Award

MouseAGE member, Dr. Ralph Müller received this year an Advanced Grant of the European Research Council (ERC). His awarded project,  "MechAGE – In vivo single-cell mechanomics of bone adaptation and regeneration in the aging mouse", is directly related to the MouseAGE activities and was very much inspired by all the discussions had so far in the aim of the consortium about investigating and modeling the aging mouse.

Ralph Müller, Professor of Biomechanics, is interested in how mechanical vibrations influence bone development. His main focus is the understanding of how bones adapt and regenerate over the course of a lifetime. In his ERC project, Müller aims to investigate which cell types are involved in these processes and how these cells react to age-related change. Specifically, he wants to use genome sequencing of single cells to understand how molecular ageing processes under mechanical loads affect bone remodelling. In the future, this understanding may facilitate targeted exercise programmes within the context of personalised medicine to foremost prevent osteoporosis-related bone fractures or at least heal them more quickly.

The project will be funded with a total of 2.5 Million € over the next five years. Such award reinforces the relevance and importance of MouseAGE field of research.

IUBMB Focused Meeting on «Molecular aspects of aging and longevity»

Next MouseAGE annual meeting will take place at Athens in the IUBMB Focused Meeting on «Molecular aspects of aging and longevity»16-19 October, Greece.

International Union of Biochemistry and Molecular Biology (IUBMB) entrusted the organization of this focused meeting to Athens, as it was considered to be the ideal setting for gathering together young researchers and leading investigators from many countries. 

Aging is an inevitable biological process. Unravelling the fundamental molecular mechanisms of aging and longevity is a pre-requisite for developing appropriate means of increasing “healthy lifespan”. The Meeting will focus on these axes as it aims to integrate the latest research developments and new technologies from internationally acknowledged experts as well as to attract young scientists in the field and to give them the opportunity to discuss with experts. Emphasis will be given to young group-leaders and it will have an additional session for presentations by young scientists. Finally, it’ll provide several travel fellowships to young scientists, especially from the developing countries.

Some of already confirmed invited speakers:   

More information at: http://www.iubmb2017aging.org/

 

 

Useful Downloads: 

MouseAGE Working Group 3 Meeting

On the past 28th February, the working group 3 (WG3) met at the COST Association headquarters, in Bruxelles, Belgium.

The aim of the meeting was to the disccus current protocols from the different labs involved in the MouseAGE, concerning the Assessment of Cognition in Aging mice models. Keynote speakers Professor Brun Ulfhake, from Karolinska Institutet, Sweden, and Professor Kathy Magnusson, from Oregon State University, USA, joined for the discussion. Standardization of protocols is one of the major goals of the WG3.

10th World Congress on Alternatives and Animal Use in the Life Sciences

 Alternatives and Animal Use in the Life Sciences

Abstract Submission is Now Open!

Submit your abstract for the 10th World Congress on Alternatives and Animal Use in the Life Sciences at the Washington State Convention Center on August 20-24, 2017 in Seattle, Washington, USA. Abstracts can be submitted for both oral and poster sessions. Find abstract guidelines and instructions on the above website.

Abstract deadline is March 31, 2017

The theme for this Congress is “The Three Rs (Replace, Reduce, Refine) in Action.” WC10 promises to be a cutting edge scientific meeting with emphasis on the latest technologies for reduction and replacement of animals and innovations in approaches to ethics, animal welfare and public policy

 

Two post-doctoral positions available at the Victor Babes National Institute of Pathology, Bucharest, Romania

Redbrain

Two postdoctoral positions are available at the Victor Babes National Institute of Pathology, Bucharest, Romania, to examine biomarker discovery in Alzheimer’s disease.

More information regarding the two positions, including requirements and contact information, can be found on the webpages of REDBRAIN: http://www.redbrain.ro/en/

Details of the two positions can also be found in the useful downloads section below.

Useful Downloads: 

Sixth Call for STSMs Now Open

COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers from Participating COST Countries to submit applications for the 5th call for STSMs.
 

Purpose of a STSM
STSM are aimed at strengthening existing networks and fostering collaborations by allowing researchers participating in a given COST Action to visit an institution or laboratory in another Participating COST Country / an approved Near Neighbour Country institution or an approved International Partner Country institution. A STSM should specifically contribute to the overall scientific objectives of the COST Action, whilst at the same time enable researchers to learn new techniques or gain access to specific expertise, instruments and/or methods not available in their own institutions. 

The scientific objectives of COST Action BM1402 are available in the Memorandum of Understanding which can be downloaded here: 

http://www.cost.eu/COST_Actions/bmbs/Actions/BM1402

 

Deadline for applications to be submitted:  ongoing call, applications will be considered on a first come first served basis providing applicants meet the requirements. STSMs must be completed place  before 10th April 2017


Notification of application outcome: 2 weeks after application submission


Period for STSM: between 27th January 2017 and 10th April 2017

 

If you have applied for an STSM you must also use the following link to record your details: http://goo.gl/forms/S1HwZ3Pkvo

If you have questions regarding STSMs please email the  STSM coordinator Roosmarijn Vandenbroucke. The full details of this call can be found in the document below: 'COST Action BM1402 STSM 6th Call'.

Useful Downloads: 

Fronteirs Research Topic now welcoming contributions

The Hormones and Neural Aging: Lessons from Experimental Models Fronteirs Research Topic is now accepting submissions.

About this Research Topic

The study of aging by using experimental models offers an opportunity to understand human physiopathology, which complements clinical and epidemiological studies.

The relationship between the hormonal status and neural aging has been studied in different contexts, from metabolism to reproduction. Neural aging is associated with modifications in the levels of different peripheral neuroprotective hormones, as it is also affected the sensitivity of neurons and glial cells to respond to peripheral metabolic signals. In turn, neural aging affects the control exerted by the hypothalamus on peripheral endocrine glands and body metabolism. Therefore, the feed-back loops between the brain and the body are progressively altered during the aging process, contributing to neural dysfunction.

The research topic proposes to connect these studies with the current knowledge on the neurodegeneration of brain and sensory systems that takes place alongside aging. Molecular pathways implicated in the decreased cell renewal, cell senescence and cell death, as well as potential strategies to promote healthy brain aging and rejuvenation will be presented.

Keywords: Apoptosis, insulin-like factors, neurodegeneration, senescence, sex hormones

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area

 More information can be found here: http://journal.frontiersin.org/researchtopic/5664/hormones-and-neural-aging-lessons-from-experimental-models

PhD Studentship: University of Sheffield, UK. Closing date for Applications 6/1/17

DiMeN DTP

DiMeN Doctoral Training Partnership: An epigenetic approach to healthy ageing; modulating cellular senescence

Over 60% of people aged over 65 have multiple age-related chronic diseases. The accumulation of deficits resulting from multimorbidity leads to frailty, with loss of independence. Over 80% of the medicare budget in the US is spent on care for frailty and multimorbidity. The current treatment based on targeting each disease individually is not effective due to polypharmacy and the accumulation of side effects. New interventions, which target fundamental ageing processes, and therefore reduce the impact of multimorbidity and frailty, are required(1). 

Accumulation of DNA damage with age is one of the main mechanisms of ageing leading to cellular senescence, the accumulation of which is detrimental to tissue maintenance and repair(2). Genetic removal of senescent cells has been shown to reduce onset of multiple age-related diseases, suggesting it is an excellent target for intervention(3). In our previous work we have shown that inhibition of a histone demethylase in aged human mesenchymal stem cells (hMSC) promotes the repair of DNA damage, and reverse senescence. This resulted in the extension of hMSC lifespan. Our hypothesis is that inhibition of this target gene will reduce cellular senescence in an aged mouse, leading to delayed beneficial health outcomes. We have an inducible mouse knock out (http://www.mousephenotype.org) and shown that conditional ablation of this gene in adult mice leads to over 90% reduction in expression with no adverse effects on the mice. 

We plan to determine; 

1. The network of genes responsible for the enhanced DNA damage response and involved in the reversal of senescence. 

2. Whether ablation of the histone demethylase in ageing mice leads to reversal of accumulation of DNA damage and cellular senescence, particularly in stem cells, and if this results decreased signs of age-related disorders and frailty. We will induce the deletion of the histone demethylase when mice are 18 months of age. When mice starts showing deficits. We will measure the amount of cellular DNA damage and senescence accumulated in tissues by immunostaining using a combination of markers known to identify senescent cells: ɣH2AX and 53BP1, p16, p21, PCNA. These protocols are well established in the laboratory of the primary supervisor. We will assess mice health using the Harwell phenotypic pipeline, to test function across the cardiac, metabolic, immune, musculoskeletal and sensory systems as well employing cognitive and behavioural tests. We will also measure the frailty index which has been established in both supervisors’ laboratory. We will perform a more in depth analysis of the musculoskeletal system by focusing on the analysis of bone for signs of improved bone loss (bone structure by microCT, cellular composition by histomorphometry, bone strength, stem cell function) and reduced osteoarthritis-like signs in the joint (medial plateau trabecular thickness, OARSI score, number of osteophytes) and muscle deterioration (fibre number, size and type, functional stem cell analysis). We will monitor survival and cause of death by necropsy and pathology at the time of sacrifice. 

This project is a collaborative effort between the MRC Arthritis Research UK Centre for Integrated Research Into musculoskeletal Ageing (CIMA) at the University of Sheffield and Liverpool and the MRC Harwell Institute. It will provide a unique opportunity for a student to gain experience in cutting edge in vitro and in vivo techniques and take advantage of the facilities and expertise of 3 leading institutions. The supervisors are leading the COST Action MouseAge which brings together researchers from 25 European countries and holds training schools in ageing and interventions. The student will be part of this network with excellent training opportunities. The student will be based in Sheffield but expected to complete approximately a year’s study in Harwell undergoing training in phenotyping and carry out in vivo ageing studies. In addition they will visit Liverpool to learn histological analysis of muscle. 

Supervisors: 
Professor Ilaria Bellantuono (University of Sheffield) 
Dr Paul Potter (MRC Harwell) 
Dr Katarzyna Goljanek-Whysall (University of Liverpool) 
 

Funding Notes

DiMeN DTP studentships are funded for 3.5 years and include: 

- Tax-free maintenance grant set at the UK Research Council's national rate. 
- Full payment of tuition fees at the Home/EU rate. 
- A Research Training Support Grant to support your research studies. 

Successful Home students will receive a full studentship. EU students will be considered for a full studentship/fees only support depending on the excellence of their qualifications and their employment/residency status. 

Please carefully read the instructions on eligibility and how to apply at our website and use the link on the page to submit an application: http://www.dimen.org.uk/how-to-apply/application-overview

References

1. Figueira I, Fernandes A, Mladenovic A, Lopez-Contreras A, Henriques CM, Selman C, Ferreiro E, Gonos ES, Trejo JL, Misra J, et al. Interventions for age-related diseases: shifting the paradigm. Mech Ageing Dev. 2016. 
2. Childs BG, Durik M, Baker DJ, and van Deursen JM. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med. 2015;21(12):1424-35. 
3. Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, A. Saltness R, Jeganathan KB, Verzosa GC, Pezeshki A, et al. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature. 2016;530(7589):184-9.

More Information

http://www.dimen.org.uk/

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=80610&LID=3411

https://www.findaphd.com/search/PhDDetails.aspx?CAID=2959&LID=348

 

IUBMB Focused Meeting on Molecular aspects of aging and longevity

IUBMB meeting logo

It is our privilege and special pleasure to invite you to the IUBMB Focused Meeting on “Molecular aspects and longevity” on October 16th - 19th 2017 in Athens, Greece.

IUBMB entrusted the organization of this focused meeting to Athens, as it was considered to be the ideal setting for gathering together young researchers and leading investigators from many countries. 

Aging is an inevitable biological process. Unravelling the fundamental molecular mechanisms of aging and longevity is a pre-requisite for developing appropriate means of increasing “healthy lifespan”. The Meeting will focus on these axes as it aims to integrate the latest research developments and new technologies from internationally acknowledged experts as well as to attract young scientists in the field and to give them the opportunity to discuss with experts. We aim selecting few additional speakers from the participants. Emphasis will be given to young group-leaders and we will have an additional session for presentations by young scientists. Finally, we’ll provide several travel fellowships to young scientists, especially from the developing countries.

In this context, we look forward to welcoming you in Athens, the heart of European culture and civilization, and receiving you according to the traditional Greek hospitality.


With my best regards,

Efstathios S. Gonos,
Director of Research
IUBMB Executive Committee Member for Congresses and Conferences

Meeting Topics: 

  • Age-related diseases & clinical studies
  • DNA damage and repair
  • Genetics and epigenetics
  • Immunity and aging
  • Model systems
  • -omics in aging research
  • Proteostasis & protein maintenance systems.
  • Stem cells & anti-aging strategies
  • Telomeres & telomerase

Key dates:

Deadline for abstract submission: May 1st, 2017

Notification of acceptance / rejection: May 15th, 2017

Deadline for early registration: June 1st 2017

Deadline for young scientists’ fellowships: May 1st 2017

For more information visit the IUBMB 2017 website: http://www.iubmb2017aging.org

International Conference on Frailty and Sarcopenia Research 2017

ICFSR 2017

Thursday 27th - Friday 28th April 2017

Barcelona, Spain

Key note speakers: Marco Pahor, Gainesville, USA, Leocadio Rodríguez-Mañas, Getafe, Spain, Alfonso Cruz-Jentoft, Madrid, Spain, Stephen Donahue, Savannah, USA, Tommy Cederholm, Uppsala, Sweden and Roger Fielding, Boston, USA.

Abstract submissions in the areas of SARCOPENIA (Biology • Animal models • Preclinical studies • Clinical trials • Functional assessment • Biomarkers and imaging • New drug developments • Physical exercise • Nutrition intervention • Epidemiology), FRAILTY (• Biology of frailty and aging •Cognitive frailty • Physical frailty and age-related body composition modifications • Frailty in clinical practice and public health • Clinical trials and therapeutics) and OSTEOPOROSIS (• Osteoporosis & Frailty • Osteoporosis & Sarcopenia) are welcomed.

Call for abstracts: Symposium/Oral communication/Poster deadline: 12th December 2016

For more information see the conference flyer below or visit the ICFSR 2017 website: http://www.frailty-sarcopenia.com/

Useful Downloads: 

Fifth Call for STSMs Now Open

MouseAGE Logo

COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers from Participating COST Countries to submit applications for the 4th call for STSMs.
 

Purpose of a STSM
STSM are aimed at strengthening existing networks and fostering collaborations by allowing researchers participating in a given COST Action to visit an institution or laboratory in another Participating COST Country / an approved Near Neighbour Country institution or an approved International Partner Country institution. A STSM should specifically contribute to the overall scientific objectives of the COST Action, whilst at the same time enable researchers to learn new techniques or gain access to specific expertise, instruments and/or methods not available in their own institutions. 

The scientific objectives of COST Action BM1402 are available in the Memorandum of Understanding which can be downloaded here: 

http://www.cost.eu/COST_Actions/bmbs/Actions/BM1402

Deadline for applications to be submitted: 30th November 2016

Notification of application outcome: 3 weeks after application submission
Period for STSM: between 31st October 2016 and 28th Feb 2017

All STSM activities must occur in their entirety within the period specified above.

If you have applied for an STSM you must also use the following link to record your details: http://goo.gl/forms/S1HwZ3Pkvo

If you have questions regarding STSMs please email the  STSM coordinator Roosmarijn Vandenbroucke. The full details of this call can be found in the document below: 'COST Action BM1402 STSM 4th Call'.

Useful Downloads: 

TAmiRNA presents the new osteomiR test kit – a unique molecular diagnostic kit for detection of osteoporosis

TAmiRNA

The Austrian spin-off TAmiRNA develops biomarker solutions, which significantly improve early detection of serious age-related illnesses such as osteoporosis. At this years American Society for Bone and Mineral Research meeting in Atlanta, Georgia (USA). TAmiRNA presents the new osteomiR test kit – a unique molecular diagnostic kit for detection of osteoporosis.

For those at the ASBMR meeting, please, visit TAmiRNA at booth Nr 613 for some Austrian sweets, information on the osteomiR kit and chance to win a 2-day workshop in Vienna, Austria.

Visit the TAmiRNA website for further information. 

Useful Downloads: 

INFRAFRONTIER-I3 / Mouse Metabolic Phenotyping Training Course

Infrafrontier

10th -13th October 2016 

German Mouse Clinic,Helmholz Centre, Munich  

INFRAFRONTIER, the European Research Infrastructure for phenotyping and archiving of model mammalian genomes, offers an excellent training opportunity in mouse metabolic phenotyping. The course will be run by the German Mouse Clinic (GMC) based at the Helmholtz Centre Munich (https://www.mouseclinic.de/index.html), and will cover state of the art phenotyping assays used in the energy metabolism, diabetes, clinical chemistry and pathology screens of the GMC. All assays are routinely applied in systemic phenotyping projects of the GMC, and in part also in the phenotyping pipeline of the International Mouse Phenotyping Consortium (IMPC). The course will be run by highly experienced scientists of the GMC, and involve presentations and extensive discussions of assays, experimental design and data analyses.

Learning objectives

The 4-day course is intending to give participants a comprehensive overview of state of the art technologies and approaches in mouse metabolic phenotyping. A strong focus will be on experimental design and phenotyping data analyses

Prospective attendees

Course level will be at MS, PhD and Postdoc level. No prior experience with metabolic phenotyping required

Programme

Day 1 / October 10th / starting at 12.00

- German Mouse Clinic phenotyping pipelines, INFRAFRONTIER

- Glucose metabolism, glucose tolerance test

- Clamp technologies

Day 2 / October 11th

- Metabolic phenotyping

- Clinical chemistry / liver enzymes

- Pathology and histological analyses

- Tour of German Mouse Clinic

Day 3 / October 12th

- Phenotyping pipeline design

- Data analysis, statistics

- Liver spectroscopy, Maldi mass spectrometry

- Breath gas analysis

- Metabolomics

- Tour of Helmholtz Genome Analysis Centre (GAC)

Day 4 / October 13th / ending at 17.00

- Pigs as animal models for metabolic research

- Indirect calorimetry

- Human respirometry

Information

The training course is limited to a total of 10 participants

Cost: 500€ covering course materials, accommodation, coffee breaks, lunch and course dinner (but excluding travel cost)

Accommodation for course participants has been arranged in the Kurfürst Hotel close to the meeting venue, http://www.kurfuerst-hotel.de/

Registration deadline: September 16th, 2016

 A registration form can be downloaded from the INFRAFRONTIER portal athttps://www.infrafrontier.eu/resources-and-services/training-and-consulting-services/phenotyping-training-courses

 For further enquiries and submission of applications: training@infrafrontier.eu

The INFRAFRONTIER metabolic phenotyping training course is financially supported by the EC FP7 funded INFRAFRONTIER-I3 project, project No: 312325

 

Job position advertisement

Lab Head/Research Investigator (Ph.D. level)

Musculoskeletal Disease Area – Muscle #194706BR

 

Job Description

The Muscle group in Cambridge, US, is seeking for a highly motivated Ph.D. level scientist to join our early stage drug discovery department. As head of an in vitro research lab with 2 to 3 associates you will be responsible for exploring new muscle disease mechanisms and potential treatments including target identification, validation and subsequent drug discovery research. Our focus is on targeting pathway dysregulation nodes in disease, subsequently identifying drug candidates and profiling them in relevant disease models. In the role, you will be developing in vitro and ex vivo functional and phenotypical assay systems using emerging technologies. You will be part of an interdisciplinary, highly collaborative group.

The successful candidate will be responsible for:

- Conducting cell, molecular biology and biochemistry experiments. 

- Development and implementation of disease-relevant cellular systems with phenotypical and functional readouts using healthy and patient primary and iPS cells.

- Training, developing and mentoring associates and closely collaborating on all levels.

- Independent planning, execution, documentation, analysis and interpretation of experiments.

- Presentation of results in both written and oral format and delivery of completed reports within a multidisciplinary team environment.

 

Requirements

  • Ph.D., MD or DVM in  biochemistry, cell biology, genetics, systems biology, or related field
  • Experience in target identification, validation and working with primary cells, or establishing cellular assays, or extensive cellular signaling experience, with an emphasis on disease pathways would be helpful
  • Experience with physiologic assays using human or patient cells, or iPS cells or functional (e.g. calcium, contraction) or phenotypical readouts would be a plus
  • Is well-organized and used to work in an interdisciplinary team environment.
  • Proficiency in standard informatics tools.
  • Three to five years of experience, ideally in industry or drug discovery: musculoskeletal research experience would be additionally desireable

More information: https://sjobs.brassring.com/tgwebhost/jobdetails.aspx?partnerid=13617&siteid=5260&jobid=2436779&_ga=1.190091491.913167989.1470856948

Meeting: Developing interventions for frailty: what do we measure?

14th - 15th November 2016

InterCityHotel, Vienna, Austria

Confirmed Speakers: Thomas von Zglinicki (Newcastle University, UK), Roger Fielding (Tufts University, USA), Roberto Bernabei (Università Cattolica del Sacro Cuore, Italy), Alexander Bürkle (Universität Konstanz, Germany), Sophie Lemire-Brachat (Novartis, Switzerland), Evgeni Levin-Tsivtsivadze (University of Amsterdam, The Netherlands), Patrik Christen (ETH Zurich, Switzerland) and Clemens Löwik (Erasmus MC, The Netherlands).

There will be a number of bursaries available for researchers to attend the meeting- these will cover accommodation, travel and meals in line with COST reimbursement rules. COST rules on reimbursement are detailed in the COST vademecum which can be found here: http://www.cost.eu/participate. Reimbursement will occur after the meeting.

Abstracts are encouraged to be submitted from the network for poster presentation in the themes of the meeting: ageing and age-related diseases, models of frailty, assessment of frailty, biomarkers of frailty, new technologies for biomarker analysis and measures of performance. Please use the registration form to submit an abstract. Abstracts should be no longer than 300 words.

Please use this form HERE to apply for a bursary and to register your interest in attending.

Deadline for abstract submission and bursary applications: 9th September 2016

Applicants will be notified on the outcome of their application week commencing 19th September 2016.

For queries please contact: mouseage@sheffield.ac.uk

Training School: Introduction to Mathematical and Computational Modelling

Eindhoven University of Technology

From mouse to computer and back

17th - 19th January 2017

Eindhoven University of Technology, Eindhoven, the Netherlands

The training school provides an introduction to mathematical and computational modelling for scientists that work with animal models of disease. The training school aims to show how such techniques can contribute to biomedical research, in particular to integrate data and knowledge and facilitate translation of preclinical findings. It will also discussed how experiments are tailored to deliver data that is amenable for computation, and how modelling provides predictions and hypotheses as input for further experimental work. The participants will be exposed to some of the underlying mathematics, but the main focus will be on concepts and principles. The program is composed of lectures, hands-on computer practicals and research presentations. Computers with software are available

Confirmed Lecturers:

  • Natal van Riel (TU/e)
  • Steven Niederer (King’s College London)
  • Enrico Dall'Ara (University of Sheffield)
  • Carly Taylor (ETH Zürich)

More information regarding the training school and how to apply can be found here.

DEADLINE FOR APPLICATIONS: FRIDAY 30th SEPTEMBER 2016

Research Opportunity: Autonomous University of Madrid (UAM) and Ciberned, Spain

Autonomous University of Madrid (UAM)

Antonio Cuadrado, MouseAGE member, is looking for an enthusiastic candidate with a strong background in Molecular Biology that might want to integrate into his team at the Autonomous University of Madrid (UAM) and Ciberned, Spain.

The lab focuses on understanding the relevance of transcription factor Nrf2 as a new target to combat oxidative, inflammatory and proteotoxic stress in neurodegenerative diseases.

The candidate together with Antonio will apply  to the new postdoctoral contracts, “Modalidad 2”, just lunched by the Community of Madrid. The bases of this call can be found at: https://www.bocm.es/boletin/CM_Orden_BOCM/2016/06/20/BOCM-20160620-24.PDF

For further information about the team and the call, please contact Antonio by email: antonio.cuadrado@uam.es

Fourth Call for STSMs Now Open

MouseAGE

COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers from Participating COST Countries to submit applications for the 4th call for STSMs.


Purpose of a STSM

STSM are aimed at strengthening existing networks and fostering collaborations by allowing researchers participating in a given COST Action to visit an institution or laboratory in another Participating COST Country / an approved Near Neighbour Country institution or an approved International Partner Country institution. A STSM should specifically contribute to the overall scientific objectives of the COST Action, whilst at the same time enable researchers to learn new techniques or gain access to specific expertise, instruments and/or methods not available in their own institutions. 

The scientific objectives of COST Action BM1402 are available in the Memorandum of Understanding which can be downloaded here: 

http://www.cost.eu/COST_Actions/bmbs/Actions/BM1402

Deadline for applications to be submitted: ongoing call, applications will be considered on a first come first served basis providing the applicant meets the requirements
Notification of application outcome: 3 weeks after application submission
Period for STSM: between 1st April 2016 and 28th Feb 2017

All STSM activities must occur in their entirety within the period specified above.

If you have applied for an STSM you must also use the following link to record your details: http://goo.gl/forms/S1HwZ3Pkvo

If you have questions regarding STSMs please email the  STSM coordinator Roosmarijn Vandenbroucke. The full details of this call can be found in the document below: 'COST Action BM1402 STSM 4th Call'.

Useful Downloads: 

Job Opportunity: ERA Chair of Clinical Genomics and Personalized Medicine

University of Tartu

The University of Tartu is seeking a senior level researcher (R3 or R4 level) to serve as the ERA Chair of Clinical Genomics and Personalized Medicine to lead a team of researchers within the National Centre for Translational Medicine (CTM).

The candidate should have experience in a R&D institution for at least 5 years post-doctoral period and have produced at least 20 papers during the last 5 years.

The candidate should have the following expertise:

• genetics of complex diseases and comorbidites;
• genetic epidemiology;
• analysis of animal models for complex diseases;
• experience in eQTL mapping;

Experience in managing a lab, budgeting and a successful track record in project writing are valuable.

Salary/Contract Information: Contract will be for five years (the length of the EU supported ERA Chair project) with a competitive salary that is commensurate with experience of the applicant.

More information on the role of the ERA Chair can be found in the document below.

 

Useful Downloads: 

The Buck Institute For Research On Aging: New International Partner of MouseAGE

The Buck Institute For Research On Aging

MouseAGE is pleased to announce the addition of The Buck Institute For Research On Aging as an international partner of the COST Action. The representative member will be Prof. Brian Kennedy, Buck Institute CEO. Prof. Kennedy has an international reputation for his work in the basic biology of aging and the pathways that modulate longevity in life forms ranging from yeast to mice.  

“The work being done at the Buck Institute for Age Research raises the possibility to intervene in the aging process.  Aging is the biggest risk factor for many diseases, therefore success in slowing aging will likely make people healthier later in their lifespan.’’ - Brian K. Kennedy, PhD

“The addition of the Buck Institute to the Action is an important step forward in joining efforts among major ageing research Institutes worldwide to speed up progress in bringing new interventions to the clinic. This will also benefit greatly our early stage researchers who will have the opportunity to visit the Buck Institute on a collaborative basis through STSMs.” - Ilaria Bellatuono, MouseAGE Chair

For further information visit:

https://www.buckinstitute.org/kennedyLab

https://www.buckinstitute.org/BrianKennedy

VPHi webinar - Computer models in biomedicine: What for?

VPH Institute

Tuesday 12th April 2016

11:00 AM - 12:00 PM BST

 

Biomedical research and clinical practice rely on complex and multimodality datasets for the characterisation of human organs in health and disease. In computational biomedicine, it is often argued that multiscale computational models are and will be increasingly required as tools for data integration, for probing the established knowledge of physiological systems, and for predictions of the effects of therapies and disease. 

But what has computational biomedicine delivered so far? 
Prof Blanca Rodriguez from Oxford University will provide examples of different types of successful uses of computational models in cardiac research from basic to translational science. The VPHi student member, Haibo Ni from Manchester University will moderate the session. 

This webinar belong to the VPHi keynote webinar series, a quarterly event organised by the VPHi student committee that provides a forum for access to senior community members and their expert competence for chiefly young scientists but also to the VPH community as a whole. 

Register to Attend HERE

Auditory Neuroscience Summer School

6th -8th July 2016 - Madrid, Spain

Become familiar with current research topics in Auditory Neuroscience. This event is organised by TARGEAR

The Auditory Neuroscience Summer School will take place at the School of Medicine of Universidad Autónoma de Madrid.

The school aims to provide a forum to learn state-of-the-art procedures to study hearing disorders. Students will have the opportunity to learn from experts a series of techniques, including, but not limited to: electrophysiology recording, developing and adult inner ear sample preparation for histology and gene expression analysis. In addition, the course will teach the participants the main indications of surgical and non-surgical devices for the current treatment of hearing loss. This practical course is designed to provide the participants with general knowledge to carry experimental work in the inner ear of lab animals. Limited seats are available to ensure a more personalized experience.

Registration is open to anyone with an interest in Hearing Research, including scientists, clinicians, engineers, audiologists, science students, etc.

More details and the School´s preliminary programme, as well as on line registration, are available at the following link: http://congresos.fuam.es/fuamcongresos/auditory-neuroscience-summer-school-2016/home

The TARGEAR project is an Industry-Academia Partnerships and Pathways (IAPP) – Marie Curie Action constituted by experienced research groups in complementary fields ranging from the molecular to the clinical aspects of age-related hearing loss. The general objective is to develop a collaborative strategy between public research institutes and private companies, based in transfer of knowledge, to design and implement preclinical studies for presbyacusis.

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Herman Bouma Fund for Gerontechnology Foundation GRANTS AVAILABLE

The Herman Bouma Fund for Gerontechnology Foundation has the objective to stimulate the further development of Gerontechnology, both nationally and internationally. The foundation will support young, promising researchers in this area with yearly grants for travel and/or research scholarships.Young and promising researchers are able to apply to the Herman Bouma Fund for Gerontechnology Foundation for a grant. An award of up to 1000 EURO is available. The deadlines for submitting grant applications are:

March 20, 23:59 CET
October 20, 23:59 CET

For more information on how to apply please visit: http://gerontechnologie.nl/grants/

Epigenetic and Metabolic Regulation of Aging and Aging-Related Diseases (E1)

May 1—5, 2016

Hilton Santa Fe Historic Plaza Hotel, Santa Fe, New Mexico, USA

Scientific Organizers: Anne Brunet, David M. Sabatini and Shelley L. Berger

Aging is one of the greatest fundamental mysteries in biology, and arguably its next frontier. Long thought to be inexorable, aging has in fact been shown to be malleable due to specific changes in genes or environment. This meeting will cover the most exciting questions at the forefront of the field: How can external stimuli delay aging in a long-lasting, yet reversible, manner? Does the integration of external stimuli to modulate aging differ among cells with vastly diverse functions – somatic maintenance, tissue regeneration and the “immortal” germline? Is aging a synchronous process, and how do the different cells and systems communicate? How do diseases of aging develop, and what can be done to prevent or reverse them? To address these questions, the symposium gathers investigators from completely different areas to bring an interdisciplinary approach to aging. The meeting will focus on the emerging nexus between two key aging regulators – epigenetic states of the genome and metabolic status – and will highlight innovative technologies and the newest discoveries in aging and diseases. It will address questions from different perspectives, taking advantage of model organisms with drastically divergent lifespans and aging strategies.  

Session Topics: Epigenetic Regulation of Aging, Workshop 1: New Animal Models, Transcriptional and Noncoding RNA Networks in Aging, Autophagy, “Inflammaging” and Metabolism, The Immortal Germline: Reprogramming and Transgenerational Inheritance, Epigenetic and Metabolic Regulation of Aging Stem Cells, Systemic Regulation of Aging, Epigenetics of Age-Related Diseases, Workshop 2: Therapeutic Approaches, Human Aging and Therapeutics

Sponsored by Journal of Molecular Cell Biology (JMCB)

DEADLINES:
Scholarship Deadline: Jan 5, 2016 
Discounted Abstract Deadline: Jan 5, 2016 
Abstract Deadline: Feb 2, 2016 
Discounted Registration Deadline: Mar 1, 2016

*Information taken from the Keystone Symposia Website*

More information available here: http://www.keystonesymposia.org/16E1#utm_source=2016E1email2&utm_medium=emaillink&utm_campaign=2016E1email2

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Cell Symposia Aging and Metabolism

Cell Symposia Aging and Metabolism

July 10th - 12th 2016, Melia Sitges, Spain

''The word "aging" encompasses a range of physiological changes in humans, human tissues, and constituent cells. Alterations in metabolism, whether at the level of small molecules, protein homeostasis, signaling patterns, or intertissue communication, underpin many of the processes that ultimately decline or shift during aging. The recent wealth of information on how perturbation of metabolic factors can accelerate or impair aging processes makes this an exciting time to convene and consider the new biology being uncovered, its potential impact on human health, and the implications for the coming age of precision medicine.

This meeting brings together scientists who have interests in aging and metabolism to explore the growing intersection between these fields and to discuss key questions in this area for human health and disease. Leaders in the field will share results from cellular research, investigations in model organisms, and studies with translational impact rooted in mammalian systems.

Themes

Human aging
Molecular aging
System/tissue crosstalk
Metabolic pathways in aging
Interventions''

Meeting information taken from Cell Symposia.

More information available at: http://www.cell-symposia-aging-metabolism.com/

MouseAGE annual meeting: 12th – 13th April 2016, Madrid, Spain

Madrid

* DEADLINE FOR REGISTRATION 31st JANURAY 2016*

COST Action BM1402 is pleased to announce that calls for abstracts and registration are now open for the MouseAGE annual meeting: 12th – 13th April 2016, NH Ventas Hotel, Madrid, Spain

Day 1: Tuesday 12th April 2016: Preclinical interventions in ageing, frailty and multimorbidity

Speakers will include: Jan Hoeijmakers (Erasmus MC, The Netherlands), Dan Ehninger (German Center for Neurodegenerative Disease, Germany), Ronenn Roubenoff (Novartis, Switzerland), Susan Howlett (Dalhousie University, Canada), Maria Blasco (Spanish National Cancer Research Centre).

Abstracts are encouraged to be submitted for oral and poster presentation in all areas covered by the aims of the Action. Particular consideration will be given to abstracts in the areas of mouse models with signs of multiple age-related disorders, frailty and on testing of preclinical interventions in these areas.

Day 2: Wednesday 13th April 2016, will comprise of a half day of parallel meetings of the four Action working groups for round table discussions.

Day 1 of the meeting is open to all.

A number of bursaries are available for ACTION members.

*Deadline for registration has now passed*

Third call for STSMs now open

MouseAGE STSM 3rd call

COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers from Participating COST Countries to submit applications for the 3rd call for STSMs.

Purpose of a STSM
STSM are aimed at strengthening existing networks and fostering collaborations by allowing researchers participating in a given COST Action to visit an institution or laboratory in another Participating COST Country / an approved Near Neighbour Country institution or an approved International Partner Country institution. A STSM should specifically contribute to the overall scientific objectives of the COST Action, whilst at the same time enable researchers to learn new techniques or gain access to specific expertise, instruments and/or methods not available in their own institutions. 
The scientific objectives of COST Action BM1402 are available in the Memorandum of Understanding which can be downloaded here: 
http://www.cost.eu/COST_Actions/bmbs/Actions/BM1402

Please see the full call for STSM Applications in the document below.

Deadline for applications to be submitted: ongoing call
Notification of application outcome: 2 weeks after application submission
Period for STSM: between 15th December 2015 and 30th March 2016
All STSM activities must occur in their entirety within the period specified above.

If you have applied for an STSM you must also use the following link to record your details: http://goo.gl/forms/S1HwZ3Pkvo

If you have questions regarding STSMs please email the  STSM coordinator Roosmarijn Vandenbroucke (Roosmarijn.Vandenbroucke@irc.vib-ugent.be)
 

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The research group Proteostasis of Aging and Stem Cells (Vilchez Lab) is seeking applications from 2 Postdoctoral fellows

Cluster of Excellence in Aging Associated Diseases (CECAD)

Two Postdoc positions are available in the group of Dr. David Vilchez at the Cologne Excellence
Cluster on Cellular Stress Responses in Aging-Associated Diseases-University of Cologne
(CECAD).

 

David's group is interested in studying how human embryonic stem cells maintain the integrity of
their proteome. Given the observation that embryonic stem cells replicate continuously in the
absence of senescence, the lab hypothesize that these cells could provide a novel paradigm to study
the regulation of proteostasis and its failure in aging. The laboratory uses an innovative approach
based on a combination of human stem cells research with genetic analysis in C. elegans and
mouse models to uncover new mechanisms for extending longevity and healthspan.

The starting date is 01/04/2016 for an initial period of 2 years with the possibility to be extended
up to 5 years in total. The salary will be according to TV-L13.


Location: The research environment in the Cologne campus is stimulating and dynamic, and
offers many interactions with other groups interested in aging research and integration in the
Cluster of Excellence in Aging Associated Diseases (CECAD).


Required Qualifications: The successful candidate must have a PhD in science (e.g., biology). We seek
enthusiastic and highly motivated postdocs interested in stem cell and aging research. Fluency in
written and spoken English is required. Experience in stem cell research, C. elegans or mouse
models is an advantage but not necessary.


How to apply:
Candidates should send:
1) Curriculum vitae
2) Written summary of research achievements and research interests (max one page).
3) The contact details of three referees.
Applications should be sent by email as ONE pdf document to Dr. David Vilchez
(dvilchez@uni-koeln.de).

 

For further information about the laboratory and the job offer, please contact Dr. David Vilchez and visit the websites:
http://vilchez.cecad-labs.uni-koeln.de/Home.545.0.html
http://vilchezlab.com

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Coordinating the infrastructure needs in Europe

MouseAGE is opening a call for European researchers to establish their infrastructure needs in the area of ageing and age-related disorders at the preclinical stage with a view to coordinate efforts for applications for funding.

Therefore the MouseAge network will perform a scoping exercise to determine:
1. Which infrastructures are already present in Europe and could become part of a larger network of collaborating facilities, open to other investigators in Europe to facilitate them in performing preclinical testing of interventions in a standardised way.

2. What are the infrastructures which would accelerate research progress in the area of preclinical intervention for ageing and age-related diseases.

Researchers from across Europe are invited to assist in this scoping exercise by completing a short 5 minute survey on infrastructure needs which is available via this link: http://goo.gl/forms/KPsOK0wwzZ Responses should be submitted by 15th January 2016.

Senior Scientist Position Opportunity - ERA Chair in Cellular and Molecular Biology of Ageing

ERA Chair

The University of Coimbra, Portugal has been awarded an ERA Chair project (WIDESPREAD – H2020), aimed at recruiting a senior researcher (ERA Chair holder) and their research group. The research should be devoted to the study of the molecular and cellular mechanisms of ageing (and age-related diseases) using non-mammalian organisms, for example the nematode C. Elegans.

More information can be found at http://www.uc.pt/en/fmuc/ibili/erachair

 

Collaboration Opportunities: Glenn Center for Aging Research

The University of Michigan Glenn Center for Aging Research is accumulating tissues from male and female mice that have been treated with drugs known to extend lifespan, specifically Rapamycin, Acarbose, and 17-alpha-estradiol.  Tissues from control mice and from mice on a calorie-restricted diet are also available. 

Rapamycin, an inhibitor of mTOR, has been shown to extend lifespan by 10% - 13% in males, and by 18% - 21% in females at the dose currently being used, i.e. 14 ppm.  Many other age-sensitive traits also show slower change in rapamycin-treated mice.

Acarbose, which is thought to remain in the gastrointestinal tract and blunt post-prandial glucose surge by inhibition of starch digestion, increases median lifespan by 22% in males.  Acarbose-treated females show a much smaller, though still significant, increase in median lifespan, i.e. 5% compared to controls.

17-a-estradiol (17aE2) is a non-feminizing steroid that mimics some of the physiological effects of estrogen (17-b-estradiol) by unknown pathways that are independent of the classical estrogen receptors.  At the dose used, 14.4 ppm, 17aE2 increases median lifespan in males by 19% but does not increase lifespan of female mice.

With a few exceptions, tissues are taken from mice at age 12 or age 22 months.  All of the tissues are from genetically heterogeneous mice of the UM-HET3 stock, bred with an equal contribution of alleles from C57BL/6J, BALB/cByJ, C3H/HeJ, and DBA/2J grandparents. 

Some of these materials are already available, and others will enter the archive within the next year.  Researchers interested in discussing collaborative research projects that involve work on these tissues are asked to contact Dr. Richard Miller at millerr@umich.edu.

Background reading:

Miller RA et al., Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell. 2014, 13:468-77. PMID:24341993.

Harrison DE et al., Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 2014 13:273-82. PMID: 24245565.

Wilkinson JE et al., Rapamycin slows aging in mice. Aging Cell 2012 11:675-82. PMID: 22587563.

Harrison DE et al., Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009 460:392-5. PMID: 19587680.

Miller RA et al., Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011 66:191-201. PMID: 20974732.

Nadon NL et al., Design of aging intervention studies: the NIA interventions testing program. Age (Dordr). 2008 30:187-99. PMID: 19424842.

MHRA Innovative Medicines Symposium: supporting innovative medicines development

MHRA Innovative Medicines Symposium

About the event

The MHRA Innovative Medicines Symposium offers industry professionals and academics the opportunity to hear from MHRA and experts from the Commission on Human Medicines (CHM) about regulatory considerations and support for innovative medicines and emerging technologies. Read our collection of case studies to see how we’ve supported innovation.

The event will be held at the Westminster Conference Centre London.

MHRA experts will explain how the agency supports innovation in medicines, through scientific and regulatory advice and guidance.

The symposium is designed to help you understand more about our approach to regulation for emerging technologies, including:

  • genomics
  • complex medicinal products
  • nanomedicines

It’s also an opportunity to question our expert panel and network with peers in the sector.

At the event you can:

  • discover more about the regulatory perspectives of emerging technologies and innovative medicines
  • learn about the MHRA Innovation Office, scientific advice meetings and our early access to medicines scheme
  • hear more about accessing scientific and regulatory advice from early stage development to regulatory evaluation
  • find out about early access and adaptive licensing, including the role of expert committees and the Commission of Human Medicines (CHM)
  • network with like-minded peers, share your experiences with colleagues and put questions directly to MHRA experts

Who should attend?

The event is useful for the pharmaceutical industry and academia working to develop innovative medicines, medicinal drug devices or novel manufacturing processes. It’s an opportunity to understand the range of advice MHRA can offer before submitting your licence application and covers the current regulatory considerations.

Cost

  • Early-bird tickets non-commerical: £245.00 + VAT
  • Early-bird tickets for industry: £345.00 + VAT
  • Standard rate non-commerical: £295.00 + VAT
  • Standard rate industry: £395.00 + VAT

Register for the event today!

INSIGNEO Institute for in silico Medicine- EPSRC PhD studentships

Insigneo

The INSIGNEO institute for in silico medicine is advertising three studentships. These projects will be part of an EPSRC funded PhD network (three projects in total) where the candidates will form, together with the supervisors and co-supervisors, a research group focused on the development and improvement of current elastic registration methods in musculoskeletal applications. 

The studentships can be viewed via the links below:

http://www.sheffield.ac.uk/faculty/medicine-dentistry-health/graduateschool/prospectivepg/opp/dallara3-1.487489

http://www.sheffield.ac.uk/faculty/medicine-dentistry-health/graduateschool/prospectivepg/opp/dallara1-1.487466

http://www.sheffield.ac.uk/faculty/medicine-dentistry-health/graduateschool/prospectivepg/opp/dallara2-1.487483 

Please note the EPSRC will cover stipend and fees only for UK students