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A call is now open for Inclusiveness Target Countries (ITC) Conference Grants

ITC Conference Grants are exclusively reserved for PhD students and early career investigators (ECIs) with a primary affiliation in an institution located in an ITC. ITCs are Bosnia-Herzegovina, Bulgaria, Cyprus, Czech Republic, Estonia, Croatia, Hungary, Lithuania, Latvia, Luxembourg, Malta, Montenegro, Poland, Portugal, Romania, Slovenia, Slovakia, the former Yugoslav Republic of Macedonia, Republic of Serbia and Turkey.

The applicant must make an oral or poster presentation at the conference and must be listed in the official event/conference programme. The main subject of the presentation must be in line with the objectives of the MouseAge action BM1402 and COST must be acknowledged.

The proposed conference to be attended must take place before 30 March 2018.  Attendance at European conferences is preferred. However, conferences held elsewhere can also be considered. Conferences, meetings and other activities organized by COST/MouseAGE are not eligible.

A Conference Grant is a contribution towards the conference fee, overall travel, accommodation and meal expenses of the selected Grantee. The calculation of the financial contribution for each Conference Grant must respect the following criteria:

  • Up to a maximum of €2500 in total can be claimed by each successful applicant;
  • Up to a maximum of €160 per day can be claimed for accommodation and meal expenses;
  • Up to a maximum of €500 can be claimed for the conference fees to be incurred by the selected Grantee.

 Applications containing the following information should be sent to Mouseage@sheffield.ac.uk:

- CV

- Motivation letter containing: (1) detailed information about the conference, (2) motivation how attending is going to benefit the applicant, (3) motivation in what way the conference themes align with the aims of the MouseAge Action, and (4) a clear breakdown of the budget requested.

The applications will be reviewed by the MouseAge Action core group based on the above-mentioned criteria and will be awarded on a first come first served basis.

After the conference the successful applicants must submit a scientific report (template available and mandatory), travel documentation, and fee invoice (if applicable) within 15 days.  The grant is only paid after submission of the requested information.

For more information see inclusiveness_target_countries_conference_userguide.pdf

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INFRAFRONTIER2020 axenic service call

INFRAFRONTIER Research Infrastructure
INFRAFRONTIER2020 Project - Trans-national Access call - July 2017
Derivation of germ-free mice (axenic service) call
Call information and application form

Context and aim of the call
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA) (www.infrafrontier.eu). 

INFRAFRONTIER2020 project and microbiome research 
One of the INFRAFRONTIER2020 project aims is to develop pilot platforms and services supporting microbiome research. A service to derive germ-free (axenic) mice is now provided by three infrastructures with a long standing expertise and track record in the derivation of axenic and gnotobiotic mice, namely the Gnoto / Axenic Facility of the Instituto Gulbenkian de Ciência, the Karolinska Institutet Core Facility for Germ-free Research, and the CNRS Service Isotechnie of the PHENOMIN-TAAM infrastructure. The Karolinska Institutet has maintained a unique platform for the handling and derivation of gnotobiotic models kept under germ-free (GF) conditions since the 1960s. All infrastructures are partners and founding members of the ECGnoto network. 

The participating INFRAFRONTIER infrastructures are among very few dedicated facilities in Europe who have the required equipment and expertise to generate germ-free and gnotobiotic mice. All infrastructures routinely offer their services to external users. The participating axenic- and gnotobiology platforms support research into host-microbiota interactions to study the role of the microbiome in both health and disease. This has been the subject of extensive research and established the involvement of the microbiome in metabolism, nutrition, physiology, and immune function and showed that mammalian microbiota play crucial roles in the pathogenesis of many diseases. 

Access to the axenic service will be granted on the basis of scientific excellence and supports pilot projects for the derivation of-germ-free mice. Further breeding and characterisation of axenic mice or the development of gnotobiotic models can be offered on a fee-for-service or on a collaborative basis. 

During the course of the INFRAFRONTIER2020 project a total of 2 Trans-national Access calls for the derivation of germ-free mice supporting a total of 10 projects will be published. The second call will be released in spring 2018. 

More information and call application form: https://www.infrafrontier.eu/resources-and-services/axenic-service/infrafrontier-axenic-germ-free-service

Proposal submission to proposals@infrafrontier.eu by August 31st 2017. Proposal evaluation from September 1st to October 15th 2017. 
The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU.1.4.1.1. Developing new world class research infrastructures) 


Trans-national Access (TA) activity of the INFRAFRONTIER2020 project Free of charge mouse late-onset phenotyping service / Access modalities 

· The EC Horizon 2020 funded INFRAFRONTIER2020 project (2017 – 2020) supports eligible customers with a free of charge mouse axenic service implemented as a Trans-national Access activity providing a total of 5 access units in this first call. 
· The access unit offered covers the derivation of germ-free (axenic) mice from a breeding nucleus or from frozen materials provided by the applicants. Mice will be kept under germ-free conditions for 6-8 weeks. 
· Mutant mouse lines will be provided by the selected applicants as live animals (minimum of 10 females and 5 males) or quality controlled frozen embryos or sperm(minimum of 40 embryos or 2 straws of sperm). The participating infrastructures will transfer and breed mice under SPF conditions, and then introduce and foster 2 litters or 8 animals into one germ-free isolator until 2 months of age. Tissues or body fluids can be provided or arrangements are made for live germ-free shipments. 
· Costs: The access to the INFRAFRONTIER2020 axenic service is free of charge. However, the shipment cost of the starting material (breeding pairs or frozen material) to the infrastructures as well as a possible live germ-free animal shipment must be covered by the applicants. Extended breeding and other complementary services can be offered on a fee-for service or on a collaborative basis. 
· Eligibility: The INFRAFRONTIER2020 Trans-national Access call is open and proposals can be submitted from applicants around the world. Four projects must be allocated to applicants from EU Member States and Associated Countries, and one project can be allocated to applicants from third countries. 
· Application: Service requests for the INFRAFRONTIER2020 mouse axenic service can be made via an application form (https://www.infrafrontier.eu/resources-and-services/axenic-service/infrafrontier-axenic-germ-free-service). Applications for the Trans-national Access activity must include a short description of the project involving the germ-free mouse mutant being generated by the INFRAFRONTIER2020 TA service. 
· Selection procedure: Proposals from eligible customers for free of charge access to the INFRAFRONTIER2020 mouse axenic service will be subject to a review procedure. The review will be based on short descriptions of the projects involving the mouse mutants that will be made germ-free by the TA service. A mixed panel of members of INFRAFRONTIER and of an external Evaluation Committee will assess service requests supported by the TA activity. In addition to scientific merit of applicants, soundness of the proposal, relevance for microbiome research and feasibility will be assessed. Applicants will be informed on the outcome of the evaluation within 6 weeks after the end of the call for which the TA application was submitted. All applications will be handled with strict confidentiality. 
· Acknowledgements: Please do acknowledge any support under this scheme in all resulting publications with "Part of this work has been funded by the European Union Research and Innovation programme Horizon 2020 (Grant Agreement Number 730879). The participating infrastructure which provided the service should be specifically mentioned in any publication resulting from the service. 
· Disclaimer: Certain mouse lines may not breed under axenic conditions, and derivation attempts will then be discontinued. Two attempts will be made to derive germ-free mice for each access unit. 

 

7th Call of STSM is now open

COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers from Participating COST Countries to submit applications for the 7th call for STSMs.


Purpose of a STSM
STSM are aimed at strengthening existing networks and fostering collaborations by allowing researchers participating in a given COST Action to visit an institution or laboratory in another Participating COST Country / an approved Near Neighbour Country institution or an approved International Partner Country institution. A STSM should specifically contribute to the overall scientific objectives of the COST Action, whilst at the same time enable researchers to learn new techniques or gain access to specific expertise, instruments and/or methods not available in their own institutions. 

We welcome applications that are aligned with MouseAGE’s current scientific priorities.  

Full details of the current MouseAGE priorities can be found on the website (www.mouseage.eu) and the scientific objectives of COST Action BM1402 are available in the Memorandum of Understanding which can be downloaded here:  http://www.cost.eu/COST_Actions/bmbs/Actions/BM1402.

Complete information regarding STSMs can be found here.

INFRAFRONTIER Research Infrastructure

INFRAFRONTIER2020 Project - Trans-national Access call - June 2017
Late-onset systemic phenotyping (ageing pipeline)


Call information and application form


Context and aim of the call 
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA) (www.infrafrontier.eu).


INFRAFRONTIER2020 project and ageing 
The INFRAFRONTIER2020 project aims to develop pilot platforms and services supporting ageing research. These activities are tightly integrated with the current efforts of the International Mouse Phenotyping Consortium (IMPC, www.mousephenotype.org) to set up a standardised late-onset (ageing) pipeline. In the IMPC phase 2 a significant fraction of mutant lines will be aged and re-phenotyped to identify genes involved with late-onset disease. The INFRAFRONTIER2020 Trans-national Access call complements the highly standardised IMPC late-onset phenotyping, as existing mouse lines with different mutations and genetic backgrounds can be tested with the IMPC late-onset phenotyping pipeline.

The INFRAFRONTIER open call facilitates access for the wider biomedical research community to the unique infrastructure and scientific expertise of the MRC Harwell mouse clinic. A total of four mouse mutant lines can be tested through a broad based late-onset phenotyping pipeline in all the major adult organ systems and most areas of major human disease and will be re-phenotyped at a later stage (weeks 52-59). Access to the service will be granted on the basis of scientific excellence and supports the development and in depth characterisation of mouse models for research on ageing and age-related diseases. INFRAFRONTIER will provide open access to all tested mouse lines and their phenotyping data.

More information and call application form: https://www.infrafrontier.eu/resources-and-services/infrafrontier-open-calls/late-onset-systemic-phenotyping-ageing-pipeline 

Proposal submission to proposals@infrafrontier.eu by June 30th 2017.
Proposal evaluation from July 1st to August 15th 2017.
The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU.1.4.1.1. Developing new world class research infrastructures)


Trans-national Access (TA) activity of the INFRAFRONTIER2020 project
Free of charge mouse late-onset phenotyping service / Access modalities

  • The EC Horizon 2020 funded INFRAFRONTIER2020 project (2017 – 2020) supports eligible customers with a free of charge mouse late-onset phenotyping service implemented as a Trans-national Access activity providing a total of 4 access units.
  • The access unit offered covers the production of a cohort and a comprehensive first line phenotyping. The phenotyping will be performed at two different ages so that late onset of disease can be measured and / or the progression of disease with age.
  • Mutant mouse lines will be provided by the selected applicants either as breeding pairs or frozen embryos or sperm. MRC Harwell will breed the cohorts required for the pipelines, use the IMPC late-onset phenotyping pipeline and perform any relevant additional tests. Health status requirements to accept animals will be provided.
  • The phenotyping data will be made publicly available through a phenotyping database or as a phenotyping report. Successful applicants must submit phenotyped mouse mutant lines to the EMMA repository. An optional grace period of up to one year can be granted before data and mutant mouse lines must be released.
  • Costs: The access to the INFRAFRONTIER2020 phenotyping service is free of charge. However, the shipment cost of the starting material (breeding pairs or frozen embryos) to the MRC Harwell mouse clinic must be covered by the customers.
  • Eligibility: The INFRAFRONTIER2020 Trans-national Access call is open and proposals can be submitted from applicants around the world. Three projects must be allocated to applicants from EU Member States and Associated Countries, and one project can be allocated to applicants from third countries.
  • Application: Service requests for the INFRAFRONTIER2020 mouse phenotyping service can be made via a dedicated application form. Applications for the Trans-national Access activity must include a short description of the project involving the mouse mutant being phenotyped by the INFRAFRONTIER2020 TA service.
  • Selection procedure: Proposals from eligible customers for free of charge access to the INFRAFRONTIER2020 mouse phenotyping service will be subject to a review procedure. The review will be based on short descriptions of the projects involving the mouse mutants that will be phenotyped by the TA service. A mixed panel of members of INFRAFRONTIER and of an external Evaluation Committee will assess service requests supported by the TA activity. In addition to scientific merit of applicants, soundness of the proposal, relevance for ageing research and feasibility will be assessed. Applicants will be informed on the outcome of the evaluation within 6 weeks after the end of the call for which the TA application was submitted.

Training School - Drug Discovery and Development

COST Action BM1402 - Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers to apply for the following training school:


Drug Discovery and Development
4th-6th October 2017
Novartis Campus, Basel, Switzerland

 

The training school aims to give insights into drug discovery and development. The core of the course is an interactive and group discussion simulation of a drug discovery project from discovering to launching a new medicine. Each participant will be assigned a role in the project team and need to come prepared to the course. Participants will encounter and make decisions about various scientific challenges and possible research path. The team will choose a therapeutic indication and drug target, search for potential chemical leads, optimize and progress these leads through preclinical research, demonstrating that selected drug candidate is safe and effective in patients, advance the drug through clinical trials, and ultimately submit the drug for registration with health authorities.

 

A provisional programme for the training school is provided in Useful downloads.

There will be 18 places available for this training school. Please note that attendance at this training school requires that some pre-course preparation will need to be completed. A bursary of 780 EURO will be available to participants as a contribution to the cost of travel, accommodation and meal expenses incurred. 

Those wishing to apply should complete the following form: https://goo.gl/forms/kYWQDAHZnmbfEG8B2. Applicants should include details of their motivation for applying for this training school, why they wish to attend and how it will benefit their research, career and CV. They should also send their CV to mouseage@sheffield.ac.uk

The closing date for applications is Friday 23rd June 2017, successful applicants will be notified by Friday 14th July 2017

 

If selected to participate in the training school, you will receive an invitation via the e-COST portal. After accepting the invitation, participants will be eligible for reimbursement according to COST rules. Further details will be sent to successful applicants. 

 

Useful Downloads: 

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