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INFRAFRONTIER2020 Project - Trans-national Access call - November 2017

Call for information and applications (November 2017): INFRAFRONTIER2020 Project - Trans-national Access

INFRAFRONTIER Research Infrastructure - Precision mammalian model development

Context and aim of the call 
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA) (www.infrafrontier.eu).

Main objective of this INFRAFRONTIER open call is to facilitate access for the wider biomedical research community to the unique infrastructure and scientific expertise of the participating INFRAFRONTIER partners, to deliver novel mouse lines that will advance knowledge of human disease and will be of widespread use in biomedical science. Recent advances in genome editing technology will be used to develop new mouse models of human disease. INFRAFRONTIER will provide open access to all newly developed disease models through the European Mouse Mutant Archive (EMMA). Access to this free-of-charge-service will be granted on the basis of the applicant's research plans and the potential impact of the proposed novel mouse line on the wider biomedical research community.

During the course of the INFRAFRONTIER2020 project a total of 3 Trans-national Access calls for the development of mammalian model development supporting a total of 28 projects will be published. Further calls supporting 10 mouse model and 6 rat model development projects will be released in 2018.

More information and call application form: https://www.infrafrontier.eu/resources-and-services/infrafrontier-open-calls/precision-mammalian-model-development 
Proposal submission to proposals@infrafrontier.eu by 20 December 2017.
Proposal evaluation from 21 December 2017 to 15 February 2018.
The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU.1.4.1.1. Developing new world class research infrastructures)


Trans-national Access (TA) activity of the INFRAFRONTIER2020 project
Free of charge precision mammalian model development service / Access modalities

  • The EC Horizon 2020 funded INFRAFRONTIER2020 project (2017 – 2020) supports eligible customers with a free-of-charge mouse model development service implemented as a Trans-national Access activity supporting a total of 12 projects in this first call.
  • The access unit offered covers the production of a single F1 genome-edited mouse line (at least one individual of a F1 genome edited mouse line will be provided).
  • The model development service involves project design including prediction of off-target sites, preparation of sgRNA's and Cas9 mRNA/protein, and injection into zygotes to generate F0 founder mutant animals (C57BL/6N or C57BL/6J genetic background preferred). Selected F0 animals will be bred to germ line to produce F1 genome edited animals. Possible allele types that can be generated are indels, exon deletions (< 10kb) and point mutation insertions. Newly developed mouse models will be made available to selected applicants within an average of 12 months following provision of all required information to start the mouse production.
  • The generated mouse models will be made available to the scientific community. An optional grace period of up to 1 year for mouse resources may apply, with immediate release of mouse resources after expiry of the grace period. Mouse mutant lines will be deposited into the INFRAFRONTIER/EMMA repository for subsequent use by the scientific community. Newly developed mouse models will be owned by the production centres and will be distributed by the INFRAFRONTIER/EMMA repository using their institutional MTAs.
  • Costs: The access to the INFRAFRONTIER2020 model development service is free of charge. However, the shipment cost of the newly developed mouse models must be borne by the applicants.
  • Eligibility: The INFRAFRONTIER2020 Trans-national Access call is open and proposals can be submitted from applicants around the world. Ten projects must be allocated to applicants from EU Member States and Associated Countries, and two projects can be allocated to applicants from third countries.
  • Application: Service requests for the INFRAFRONTIER2020 model development service can be made via an application form. Applications for the Trans-national Access activity must include a short description of the research plans for utilising the newly developed mouse model that is being generated by the INFRAFRONTIER2020 TA service.
  • Selection procedure: Proposals from eligible customers for free of charge access to the INFRAFRONTIER2020 mouse model development service will be subject to a review procedure. The review will be based on short descriptions of the projects involving the mouse mutants that will be produced by the TA service. A mixed panel of members of INFRAFRONTIER and of an external Evaluation Committee will assess service requests supported by the TA activity. In addition to scientific merit of applicants, soundness of the proposal and research plans, and the beneficial impact of the proposed novel mouse line on the wider biomedical research community will be assessed. Applicants will be informed on the outcome of the evaluation within 6 weeks after the end of the call for which the TA application was submitted. All applications will be handled with strict confidentiality.
  • Acknowledgements: Please do acknowledge any support under this scheme in all resulting publications with "Part of this work has been funded by the European Union Research and Innovation programme Horizon 2020 (Grant Agreement Number 730879). The participating infrastructure which provided the service should be specifically mentioned in any publication resulting from the service.

A call is now open for Inclusiveness Target Countries (ITC) Conference Grants

ITC Conference Grants are exclusively reserved for PhD students and early career investigators (ECIs) with a primary affiliation in an institution located in an ITC. ITCs are Bosnia-Herzegovina, Bulgaria, Cyprus, Czech Republic, Estonia, Croatia, Hungary, Lithuania, Latvia, Luxembourg, Malta, Montenegro, Poland, Portugal, Romania, Slovenia, Slovakia, the former Yugoslav Republic of Macedonia, Republic of Serbia and Turkey.

The applicant must make an oral or poster presentation at the conference and must be listed in the official event/conference programme. The main subject of the presentation must be in line with the objectives of the MouseAge action BM1402 and COST must be acknowledged.

The proposed conference to be attended must take place before 30 March 2018.  Attendance at European conferences is preferred. However, conferences held elsewhere can also be considered. Conferences, meetings and other activities organized by COST/MouseAGE are not eligible.

A Conference Grant is a contribution towards the conference fee, overall travel, accommodation and meal expenses of the selected Grantee. The calculation of the financial contribution for each Conference Grant must respect the following criteria:

  • Up to a maximum of €2500 in total can be claimed by each successful applicant;
  • Up to a maximum of €160 per day can be claimed for accommodation and meal expenses;
  • Up to a maximum of €500 can be claimed for the conference fees to be incurred by the selected Grantee.

 Applications containing the following information should be sent to Mouseage@sheffield.ac.uk:

- CV

- Motivation letter containing: (1) detailed information about the conference, (2) motivation how attending is going to benefit the applicant, (3) motivation in what way the conference themes align with the aims of the MouseAge Action, and (4) a clear breakdown of the budget requested.

The applications will be reviewed by the MouseAge Action core group based on the above-mentioned criteria and will be awarded on a first come first served basis.

After the conference the successful applicants must submit a scientific report (template available and mandatory), travel documentation, and fee invoice (if applicable) within 15 days.  The grant is only paid after submission of the requested information.

For more information see inclusiveness_target_countries_conference_userguide.pdf

Useful Downloads: 

INFRAFRONTIER2020 axenic service call

INFRAFRONTIER Research Infrastructure
INFRAFRONTIER2020 Project - Trans-national Access call - July 2017
Derivation of germ-free mice (axenic service) call
Call information and application form

Context and aim of the call
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA) (www.infrafrontier.eu). 

INFRAFRONTIER2020 project and microbiome research 
One of the INFRAFRONTIER2020 project aims is to develop pilot platforms and services supporting microbiome research. A service to derive germ-free (axenic) mice is now provided by three infrastructures with a long standing expertise and track record in the derivation of axenic and gnotobiotic mice, namely the Gnoto / Axenic Facility of the Instituto Gulbenkian de Ciência, the Karolinska Institutet Core Facility for Germ-free Research, and the CNRS Service Isotechnie of the PHENOMIN-TAAM infrastructure. The Karolinska Institutet has maintained a unique platform for the handling and derivation of gnotobiotic models kept under germ-free (GF) conditions since the 1960s. All infrastructures are partners and founding members of the ECGnoto network. 

The participating INFRAFRONTIER infrastructures are among very few dedicated facilities in Europe who have the required equipment and expertise to generate germ-free and gnotobiotic mice. All infrastructures routinely offer their services to external users. The participating axenic- and gnotobiology platforms support research into host-microbiota interactions to study the role of the microbiome in both health and disease. This has been the subject of extensive research and established the involvement of the microbiome in metabolism, nutrition, physiology, and immune function and showed that mammalian microbiota play crucial roles in the pathogenesis of many diseases. 

Access to the axenic service will be granted on the basis of scientific excellence and supports pilot projects for the derivation of-germ-free mice. Further breeding and characterisation of axenic mice or the development of gnotobiotic models can be offered on a fee-for-service or on a collaborative basis. 

During the course of the INFRAFRONTIER2020 project a total of 2 Trans-national Access calls for the derivation of germ-free mice supporting a total of 10 projects will be published. The second call will be released in spring 2018. 

More information and call application form: https://www.infrafrontier.eu/resources-and-services/axenic-service/infrafrontier-axenic-germ-free-service

Proposal submission to proposals@infrafrontier.eu by August 31st 2017. Proposal evaluation from September 1st to October 15th 2017. 
The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU.1.4.1.1. Developing new world class research infrastructures) 


Trans-national Access (TA) activity of the INFRAFRONTIER2020 project Free of charge mouse late-onset phenotyping service / Access modalities 

· The EC Horizon 2020 funded INFRAFRONTIER2020 project (2017 – 2020) supports eligible customers with a free of charge mouse axenic service implemented as a Trans-national Access activity providing a total of 5 access units in this first call. 
· The access unit offered covers the derivation of germ-free (axenic) mice from a breeding nucleus or from frozen materials provided by the applicants. Mice will be kept under germ-free conditions for 6-8 weeks. 
· Mutant mouse lines will be provided by the selected applicants as live animals (minimum of 10 females and 5 males) or quality controlled frozen embryos or sperm(minimum of 40 embryos or 2 straws of sperm). The participating infrastructures will transfer and breed mice under SPF conditions, and then introduce and foster 2 litters or 8 animals into one germ-free isolator until 2 months of age. Tissues or body fluids can be provided or arrangements are made for live germ-free shipments. 
· Costs: The access to the INFRAFRONTIER2020 axenic service is free of charge. However, the shipment cost of the starting material (breeding pairs or frozen material) to the infrastructures as well as a possible live germ-free animal shipment must be covered by the applicants. Extended breeding and other complementary services can be offered on a fee-for service or on a collaborative basis. 
· Eligibility: The INFRAFRONTIER2020 Trans-national Access call is open and proposals can be submitted from applicants around the world. Four projects must be allocated to applicants from EU Member States and Associated Countries, and one project can be allocated to applicants from third countries. 
· Application: Service requests for the INFRAFRONTIER2020 mouse axenic service can be made via an application form (https://www.infrafrontier.eu/resources-and-services/axenic-service/infrafrontier-axenic-germ-free-service). Applications for the Trans-national Access activity must include a short description of the project involving the germ-free mouse mutant being generated by the INFRAFRONTIER2020 TA service. 
· Selection procedure: Proposals from eligible customers for free of charge access to the INFRAFRONTIER2020 mouse axenic service will be subject to a review procedure. The review will be based on short descriptions of the projects involving the mouse mutants that will be made germ-free by the TA service. A mixed panel of members of INFRAFRONTIER and of an external Evaluation Committee will assess service requests supported by the TA activity. In addition to scientific merit of applicants, soundness of the proposal, relevance for microbiome research and feasibility will be assessed. Applicants will be informed on the outcome of the evaluation within 6 weeks after the end of the call for which the TA application was submitted. All applications will be handled with strict confidentiality. 
· Acknowledgements: Please do acknowledge any support under this scheme in all resulting publications with "Part of this work has been funded by the European Union Research and Innovation programme Horizon 2020 (Grant Agreement Number 730879). The participating infrastructure which provided the service should be specifically mentioned in any publication resulting from the service. 
· Disclaimer: Certain mouse lines may not breed under axenic conditions, and derivation attempts will then be discontinued. Two attempts will be made to derive germ-free mice for each access unit. 

 

7th Call of STSM is now open

COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers from Participating COST Countries to submit applications for the 7th call for STSMs.


Purpose of a STSM
STSM are aimed at strengthening existing networks and fostering collaborations by allowing researchers participating in a given COST Action to visit an institution or laboratory in another Participating COST Country / an approved Near Neighbour Country institution or an approved International Partner Country institution. A STSM should specifically contribute to the overall scientific objectives of the COST Action, whilst at the same time enable researchers to learn new techniques or gain access to specific expertise, instruments and/or methods not available in their own institutions. 

We welcome applications that are aligned with MouseAGE’s current scientific priorities.  

Full details of the current MouseAGE priorities can be found on the website (www.mouseage.eu) and the scientific objectives of COST Action BM1402 are available in the Memorandum of Understanding which can be downloaded here:  http://www.cost.eu/COST_Actions/bmbs/Actions/BM1402.

Complete information regarding STSMs can be found here.

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