Mouse genetics has made major contributions to our understanding of mammalian physiology, genetics, and disease. In recent years there have been major advances in methodologies to manipulate the murine genome and the subsequent phenotypic analysis of mouse lines. In addition there are now major international resources to facilitate mouse genetics and phenotyping. This training school aims to provide an overview of recent advances in these areas by bringing together experts from across Europe. The training school will include sessions on colony management of genetically modified mice, strategies for creation of novel mutants and their subsequent analysis, and resources available such as bioinformatics resources, archives, and infrastructure. There will be an emphasis on a ‘hands on’ approach wherever possible. In addition there will be examples of the applications of novel mouse models and applications of phenotyping, and an emphasis on using mouse models to study ageing. Throughout the training school presenters will be sharing their experiences and be available for discussions with attendees. Several major national and international mouse initiatives will be represented including the Harwell Ageing Screen, The International Mouse Phenotyping Consortium, The European Mouse Mutant Archive, and Infrafrontier.
- Prof David Baker, Queen Mary’s University, London
- Prof Ilaria Bellantuono, University of Sheffield, Chair of the MouseAGE COST Action
- Prof Steve Brown, Director, Mammalian Genetics Unit, MRC Harwell, Chair of the International Mouse Phenotyping Consortium
- Dr Michael Hagn, European Mouse Mutant Archive
- Dr Paul K Potter, Head of Disease Model Discovery, MRC Harwell -Dr Sara Wells, Director Mary Lyon Centre MRC Harwell