2018 MouseAGE Annual Meeting


24 Sep 2018 to 25 Sep 2018


Università Cattolica del Sacro Cuore


Rome, Italy


The MouseAGE meeting Geroprotectors: achievements and challenges was successfully held at the Università Cattolica del Sacro Cuore, Rome, Italy on 24th – 25th September 2018.

The key themes discussed at the meeting were:

  • What’s exciting in healthspan and geroprotectors
  • Multimorbidity and Digital Health
  • Frailty and resilience

The meeting programme is below:

Monday 24th September 2018

8.30-9.00          Registration

9.00-9.05          Welcome, Giovambattista Pani (Università Cattolica del Sacro Cuore, Italy)

9.05-9.10          Introduction to the meeting, Ilaria Bellantuono (The University of Sheffield, UK)

Session 1 part 1 - What’s exciting in healthspan and geroprotectors

Chair: Adelaide Fernandes Borralho

9.10-9.40          Dan Enhinger (German Center for Neurodegenerative Diseases, Germany)

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice

9.40-10.10        Marco Demaria (European Research Institute for the Biology of Aging, Netherlands)

Cellular senescence: When multitasking becomes dangerous

10.10-10.45      Coffee break

Session 1 part 2 - What’s exciting in healthspan and geroprotectors

Chair: José Luis Trejo

10.45-11.15      Tamara Tchakonia (Mayo Foundation for Medical Education and Research, US)

Koch’s postulates: Senescent cells drive age related physical dysfunction

11.15-11.30      Alejandro Martin Montalvo (CABIMER, Spain)

Short presentation: Exploring the thyroid hormones axis for healthpan and lifespan

11.30-11.45      Hasmik Jasmine Samvelyan (The University of Sheffield, UK)

Short presentation: Associations between timing of feeding and bone's adaptive response to loading in mouse model

11.45-12.30      Poster highlights (6 x 5 min each)

12.30-14.00      Lunch

Session 2 part 1 - Multimorbidity and Digital Health

Chair: Enrico Dall'ara

14.00-14.15             Ralph Müller (ETH Zurich, Switzerland)

Why MouseAGE is interested in digital health?

14.15-14.45             Alessandra Marengoni (University of Brescia, Italy)

Prevalence, determinants and patterns of multimorbidity

14.45-15.15             Natal Van Riel (Eindhoven University of Technology, Netherlands)

Network modelling of skeletal muscle metabolism; the impact of aging and lifestyle

15.15-15.45             Coffee break

Session 2 part 2 - Multimorbidity and Digital Health

Chair: Ralph Müller

15.45-16.15             Costas Bekas (IBM Research, Switzerland)

Cognitive Discovery: Transforming R&D with AI

16.15-16.45             Alessandro Blasimme (ETH Zurich, Switzerland)

Big data and digital health in aging research: ethical implications

16.45                Poster session and wine reception

Networking Dinner


Tuesday 25th September 2018

Session 3 part 1 - Frailty and resilience

Chair: Ronald Van Os

9.00-9.15          Ilaria Bellantuono (The University of Sheffield, UK)

MouseAGE perspective on models of resilience

9.15-9.45          Kenneth Rockwood (Dalhousie University, Canada)

                        Deficit accumulation across the life course and late-life frailty

9.45-10.15        Roosmarijn Vandenbroucke (Ghent University – VIB, Belgium)

Sepsis as model of resilience: opportunities and pitfalls

10.15-10.45      Discussion: What is a model of resilience for and what should it look like?

10.45-11.15      Coffee break

11.15-11.30      Coral Sanfeliu (IIBB-CSIC, IDIBAPS, CIBERESP, Spain)

Building a proposal for testing resilience against neurodegeneration

11.30-12.00      Thomas von Zglinicki (The University of Newcastle, UK)

The senostatic metformin suppresses the development of irradiation-induced frailty in mice

12.00-12.30      Susan Howlett (Dalhousie University, Canada)

The mouse clinical frailty index tool: preclinical research applications

12.30-14.00      Lunch

Session 3 part 2 - Frailty and resilience

Chair: Paul Potter

14.00-14.30      Francesco Landi (Catholic University of Rome, Italy)

Sarcopenia as the biological substrate of physical frailty

14.30-15.00      Anne-Ulrike Trendelenburg (Novartis, Switzerland)

                        Frailty in preclinical rodent models

15.00-15.15      Ariane Scheuren (ETH Zurich, Switzerland)

Combining longitudinal µCT imaging with frailty assessments in the PolgA mouse model

15.15-15.45      Ilaria Bellantuono (The University of Sheffield, UK)

The post-MouseAGE era

15.45                Coffee break

16.00-17.00      MouseAGE Management Committee meeting (members only)