April 2017

3rd Course Mouse and Rat Bone Phenotyping

== LAST CHANCE for applying to the "3rd Course on Mouse and Rat Bone Phenotyping" ==



Objective of the Course: The aim of this course is capacitating participants to localize and to interpret the most common skeletal alterations found in mice and rats. This will occur in the context of dedicated learning sessions devoted to the study of bone anatomy, histology, immunohistochemistry, ultrastructure and imaging. Each lecture will be followed by a practical session in which participants will work with real bone specimens,radiographs,histological preparations, and images from TEM and micro-CT. In addition, the course will include seminars where specific skeletal abnormalities found in mutant mice will be discussed.

Duration: 4 days. 10-13 July 2017

Number of participants: 15 max

The course will be held at the Center for Animal Biotechnology and Gene Therapy (CBATEG) and the School of Veterinary Medicine at the Universitat Autònoma...

Postdoctoral Research Position at CEDOC, Portugal

Postdoctoral Research Position - Lysosome dysfunction in Age-related macular degeneration

A Postdoctoral position is available in the laboratory of Miguel Seabra, at the CEDOC - Chronic Diseases Research Center, Nova Medical School, Lisbon, Portugal.

In this work we aim to test new therapeutic approaches for Age-related macular degeneration (AMD). We hypothesise that AMD has it origin in the retinal pigment epithelium (RPE) due to chronic dysfunction of the lysosome. Cellular models of AMD will be generated using cell cultures of retinal pigment epithelium (RPE) and will be tested compounds that could improve lysosomal function. The results to be obtained in cellular models will guide future tests in animal models.

This grant is for 6 months, but could be extended if funding is renewed.

Please send your application including your CV, contact details, PhD certificate, a letter of motivation, and the names and contact information of two references...

ERC Advanced Award

MouseAGE member, Dr. Ralph Müller received this year an Advanced Grant of the European Research Council (ERC). His awarded project,  "MechAGE – In vivo single-cell mechanomics of bone adaptation and regeneration in the aging mouse", is directly related to the MouseAGE activities and was very much inspired by all the discussions had so far in the aim of the consortium about investigating and modeling the aging mouse.

Ralph Müller, Professor of Biomechanics, is interested in how mechanical vibrations influence bone development. His main focus is the understanding of how bones adapt and regenerate over the course of a lifetime. In his ERC project, Müller aims to investigate which cell types are involved in these processes and how these cells react to age-related change. Specifically, he wants to use genome sequencing of single cells to understand how molecular ageing processes under mechanical loads affect bone remodelling. In the future, this understanding may facilitate targeted exercise...