December 2016

Fronteirs Research Topic now welcoming contributions

The Hormones and Neural Aging: Lessons from Experimental Models Fronteirs Research Topic is now accepting submissions.

About this Research Topic

The study of aging by using experimental models offers an opportunity to understand human physiopathology, which complements clinical and epidemiological studies.

The relationship between the hormonal status and neural aging has been studied in different contexts, from metabolism to reproduction. Neural aging is associated with modifications in the levels of different peripheral neuroprotective hormones, as it is also affected the sensitivity of neurons and glial cells to respond to peripheral metabolic signals. In turn, neural aging affects the control exerted by the hypothalamus on peripheral endocrine glands and body metabolism. Therefore, the feed-back loops between the brain and the body are progressively altered during the aging process, contributing to neural dysfunction.

The research topic proposes to connect these studies with the current knowledge on the neurodegeneration of...

PhD Studentship: University of Sheffield, UK. Closing date for Applications 6/1/17

DiMeN DTP

DiMeN Doctoral Training Partnership: An epigenetic approach to healthy ageing; modulating cellular senescence

Over 60% of people aged over 65 have multiple age-related chronic diseases. The accumulation of deficits resulting from multimorbidity leads to frailty, with loss of independence. Over 80% of the medicare budget in the US is spent on care for frailty and multimorbidity. The current treatment based on targeting each disease individually is not effective due to polypharmacy and the accumulation of side effects. New interventions, which target fundamental ageing processes, and therefore reduce the impact of multimorbidity and frailty, are required(1). 

Accumulation of DNA damage with age is one of the main mechanisms of ageing leading to cellular senescence, the accumulation of which is detrimental to tissue maintenance and repair(2). Genetic removal of senescent cells has been shown to reduce onset of multiple age-related diseases, suggesting it is an excellent target for intervention(3). In...