Job offer - Postdoctoral Research Associate

Location: University of Sheffield - Faculty of Medicine, Dentistry and Health - Department of Oncology and Metabolism

Deadline for application: 11.07.2017

Contract Type: Fixed Term for 16 months


"We are seeking a highly motivated scientist to work on an Arthritis Research UK funded project entitled An epigenetic approach to healthy ageing; modulating cellular senescence in stem cells”. The main focus of this post is to investigate the effects of a small molecule, which is able to reverse senescence in mesenchymal stem cells through an epigenetic mechanism and determine whether this leads to improved health span using in vivo models of ageing, particularly in the musculoskeletal system. This is an exciting opportunity for a researcher to develop their scientific career by working as part of a highly productive team in an outstanding research environment situated in CIMA. You will use in vitro and in vivo stem cell systems and systems to assess tissue ageing and function and whether these can be ameliorated by modulation with small molecules interfering with epigenetic regulators. A proven academic track record and a commitment to a career in this area of research are essential. Experience in mesenchymal stem cells, epigenetics, and/or possession of a personal Home Office license are an advantage."


More information can be found at:


INFRAFRONTIER Research Infrastructure

INFRAFRONTIER2020 Project - Trans-national Access call - June 2017
Late-onset systemic phenotyping (ageing pipeline)

Call information and application form

Context and aim of the call 
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA) (

INFRAFRONTIER2020 project and ageing 
The INFRAFRONTIER2020 project aims to develop pilot platforms and services supporting ageing research. These activities are tightly integrated with the current efforts of the International Mouse Phenotyping Consortium (IMPC, to set up a standardised late-onset (ageing) pipeline. In the IMPC phase 2 a significant fraction of mutant lines will be aged and re-phenotyped to identify genes involved with late-onset disease. The INFRAFRONTIER2020 Trans-national Access call complements the highly standardised IMPC late-onset phenotyping, as existing mouse lines with different mutations and genetic backgrounds can be tested with the IMPC late-onset phenotyping pipeline.

The INFRAFRONTIER open call facilitates access for the wider biomedical research community to the unique infrastructure and scientific expertise of the MRC Harwell mouse clinic. A total of four mouse mutant lines can be tested through a broad based late-onset phenotyping pipeline in all the major adult organ systems and most areas of major human disease and will be re-phenotyped at a later stage (weeks 52-59). Access to the service will be granted on the basis of scientific excellence and supports the development and in depth characterisation of mouse models for research on ageing and age-related diseases. INFRAFRONTIER will provide open access to all tested mouse lines and their phenotyping data.

More information and call application form: 

Proposal submission to by June 30th 2017.
Proposal evaluation from July 1st to August 15th 2017.
The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU. Developing new world class research infrastructures)

Trans-national Access (TA) activity of the INFRAFRONTIER2020 project
Free of charge mouse late-onset phenotyping service / Access modalities

  • The EC Horizon 2020 funded INFRAFRONTIER2020 project (2017 – 2020) supports eligible customers with a free of charge mouse late-onset phenotyping service implemented as a Trans-national Access activity providing a total of 4 access units.
  • The access unit offered covers the production of a cohort and a comprehensive first line phenotyping. The phenotyping will be performed at two different ages so that late onset of disease can be measured and / or the progression of disease with age.
  • Mutant mouse lines will be provided by the selected applicants either as breeding pairs or frozen embryos or sperm. MRC Harwell will breed the cohorts required for the pipelines, use the IMPC late-onset phenotyping pipeline and perform any relevant additional tests. Health status requirements to accept animals will be provided.
  • The phenotyping data will be made publicly available through a phenotyping database or as a phenotyping report. Successful applicants must submit phenotyped mouse mutant lines to the EMMA repository. An optional grace period of up to one year can be granted before data and mutant mouse lines must be released.
  • Costs: The access to the INFRAFRONTIER2020 phenotyping service is free of charge. However, the shipment cost of the starting material (breeding pairs or frozen embryos) to the MRC Harwell mouse clinic must be covered by the customers.
  • Eligibility: The INFRAFRONTIER2020 Trans-national Access call is open and proposals can be submitted from applicants around the world. Three projects must be allocated to applicants from EU Member States and Associated Countries, and one project can be allocated to applicants from third countries.
  • Application: Service requests for the INFRAFRONTIER2020 mouse phenotyping service can be made via a dedicated application form. Applications for the Trans-national Access activity must include a short description of the project involving the mouse mutant being phenotyped by the INFRAFRONTIER2020 TA service.
  • Selection procedure: Proposals from eligible customers for free of charge access to the INFRAFRONTIER2020 mouse phenotyping service will be subject to a review procedure. The review will be based on short descriptions of the projects involving the mouse mutants that will be phenotyped by the TA service. A mixed panel of members of INFRAFRONTIER and of an external Evaluation Committee will assess service requests supported by the TA activity. In addition to scientific merit of applicants, soundness of the proposal, relevance for ageing research and feasibility will be assessed. Applicants will be informed on the outcome of the evaluation within 6 weeks after the end of the call for which the TA application was submitted.

Training School - Drug Discovery and Development

COST Action BM1402 - Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) invites researchers to apply for the following training school:

Drug Discovery and Development
4th-6th October 2017
Novartis Campus, Basel, Switzerland


The training school aims to give insights into drug discovery and development. The core of the course is an interactive and group discussion simulation of a drug discovery project from discovering to launching a new medicine. Each participant will be assigned a role in the project team and need to come prepared to the course. Participants will encounter and make decisions about various scientific challenges and possible research path. The team will choose a therapeutic indication and drug target, search for potential chemical leads, optimize and progress these leads through preclinical research, demonstrating that selected drug candidate is safe and effective in patients, advance the drug through clinical trials, and ultimately submit the drug for registration with health authorities.


A provisional programme for the training school is provided in Useful downloads.

There will be 18 places available for this training school. Please note that attendance at this training school requires that some pre-course preparation will need to be completed. A bursary of 780 EURO will be available to participants as a contribution to the cost of travel, accommodation and meal expenses incurred. 

Those wishing to apply should complete the following form: Applicants should include details of their motivation for applying for this training school, why they wish to attend and how it will benefit their research, career and CV. They should also send their CV to

The closing date for applications is Friday 23rd June 2017, successful applicants will be notified by Friday 14th July 2017


If selected to participate in the training school, you will receive an invitation via the e-COST portal. After accepting the invitation, participants will be eligible for reimbursement according to COST rules. Further details will be sent to successful applicants. 


Useful Downloads: 

3rd Course Mouse and Rat Bone Phenotyping

== LAST CHANCE for applying to the "3rd Course on Mouse and Rat Bone Phenotyping" ==



Objective of the Course: The aim of this course is capacitating participants to localize and to interpret the most common skeletal alterations found in mice and rats. This will occur in the context of dedicated learning sessions devoted to the study of bone anatomy, histology, immunohistochemistry, ultrastructure and imaging. Each lecture will be followed by a practical session in which participants will work with real bone specimens,radiographs,histological preparations, and images from TEM and micro-CT. In addition, the course will include seminars where specific skeletal abnormalities found in mutant mice will be discussed.

Duration: 4 days. 10-13 July 2017

Number of participants: 15 max

The course will be held at the Center for Animal Biotechnology and Gene Therapy (CBATEG) and the School of Veterinary Medicine at the Universitat Autònoma de Barcelona (

Tuition fee: € 950

Applications should be sent to:

Detailed information can be found in Useful Downloads.

Useful Downloads: 

Postdoctoral Research Position at CEDOC, Portugal

Postdoctoral Research Position - Lysosome dysfunction in Age-related macular degeneration

A Postdoctoral position is available in the laboratory of Miguel Seabra, at the CEDOC - Chronic Diseases Research Center, Nova Medical School, Lisbon, Portugal.

In this work we aim to test new therapeutic approaches for Age-related macular degeneration (AMD). We hypothesise that AMD has it origin in the retinal pigment epithelium (RPE) due to chronic dysfunction of the lysosome. Cellular models of AMD will be generated using cell cultures of retinal pigment epithelium (RPE) and will be tested compounds that could improve lysosomal function. The results to be obtained in cellular models will guide future tests in animal models.

This grant is for 6 months, but could be extended if funding is renewed.

Please send your application including your CV, contact details, PhD certificate, a letter of motivation, and the names and contact information of two references to with the subject “DAI/2017/14 application” from 10th April to 24th April 2017. More details about this application can be found here. 


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