Mouse aging models are important for age-related research

COST Action BM1402:MouseAGE is formed to develop a European network for preclinical testing of interventions in mouse models of age and age-related diseases.

The number of people over 65 is predicted to double in the next 50 years. Age is the most important risk factor for stroke, heart attacks, cancers, diabetes, and many other chronic diseases.

Interventions with geroprotectors hold great promise in the prevention of multiple age-related diseases and boosting resilience. However, there are barriers to their translation due to the lack of suitable animal models, validated endpoints and appropriate regulatory framework. MouseAGE brings together research scientists in academia and in industry, clinicians and members of regulatory bodies with expertise in ageing, age-related diseases, mouse models, geriatrics, drug development and clinical translation to develop together a unified research roadmap to speed up the translation of geroprotectors to clinical use.